【Erastin CAS#571203-78-6】RAS 選擇性致死性的抗腫瘤劑貨號2231(Abcam ab209693)
Erastin | CAS#571203-78-6貨號2231 (abcam ab209693)
An antitumor agent with RAS-selective lethality.
Erastin是一種選擇性抗腫瘤藥(selective antitumor agent)，在具有致癌基因HRAS，KRAS或BRAF突變的人類腫瘤細胞中顯示出更大的致死性。它與線粒體揮發性依賴性陰離子通道（mitochondrial volatage-dependent anion channels , VDAC）蛋白結合，更具體地講，與VDAC2結合併改變其門控。 erastin在具有RAS-RAF-MEK信號轉導活化突變的幾種人類腫瘤中迅速誘導氧化性，非凋亡性細胞死亡。
| Alternate Name | 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone |
| Appearance | White solid |
| CAS # | 571203-78-6 |
| Molecular Formula | C₃₀H₃₁ClN₄O₄ |
| Molecular Weight | 547.04 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>50 mg/ml) |
| SMILES | CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N4CCN(CC4)C(=O)COC5=CC=C(C=C5)Cl |
| InChi | InChI=1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3 |
| InChi Key | BKQFRNYHFIQEKN-UHFFFAOYSA-N |
| PubChem CID | 11214940 |
| MDL Number | MFCD09837984 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
