抗生素系列產品  | G418 sulfate | G418抗生素 | Antibiotic G418

G418抗生素產品內容敍述:

G418 sulfate | CAS # 108321-42-2 | BioVision Inc. 貨號1557-5G

產品原理: G418 disulfate是種氨基糖甙類抗生素，抑制原核和真核蛋白質的合成。對細菌，酵母，原生動物，蠕蟲，高等植物和哺乳動物細胞有毒性。在基因工程中廣泛被應用在真核細胞 neor基因的表達與篩選。G418 disulfate是Neomycin的類似物，兩者都是通過抑制核糖體的功能和蛋白質的合成而殺死細胞的。Neomycin對真核細胞無作用而G418抗生素對細菌和真核細胞都起作用。相關網站連結 https://www.biovision.com/g418-sulfate.html

Aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418

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