Z-VAD-FMK | 貨號1140-1MG

代理廠牌: | ![]() |
原廠連結: | |
相關下載: |
產品描述: 不可逆地 (irreversibly inhibits activity) 抑制胱天蛋白酶家族蛋白酶活性(caspase family proteases)並阻止細胞凋亡(apoptosis)的合成肽。抑制劑(inhibitor)甲酯修飾,以促進細胞通透性(cell permeability)。該產品可用於體外(in vitro)和體內(in vivo)研究。注意:如果預期用途是在純化或重組酶上,則應添加酯酶以生成游離羧基(free carboxyl groups)。
Alternate Name | Z-VAD-FMK, Z-VAD-fluoromethylketone, Caspase-Family Inhibitor (fluoromethylketone) |
Peptide Sequence | Z-Val-Ala-Asp(OMe)-FMK |
Appearance | Lyophilized solid |
CAS # | 187389-52-2 |
Molecular Formula | C₂₂H₃₀N₃O₇F |
Molecular Weight | 467.5 |
Purity | Single spot by TLC |
Solubility | DMSO (20 mM) |
SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1 |
InChi | InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31) |
InChi Key | MIFGOLAMNLSLGH-UHFFFAOYSA-N |
PubChem CID | 5737 |
MDL Number | MFCD01074990 |
Handling | Protect from light and moisture |
Storage Conditions | -20°C |
Shipping Conditions | Gel Pack |
USAGE | For Research Use Only! Not For Use in Humans. |
穀胱甘肽過氧化物酶活性測定 | FRAP檢測 | 總膠原蛋白分析 | Dopamine多巴胺檢測 | 三酸甘油酯分析 | Cholesterol Efflux膽固醇排出分析 | 脂質過氧化(MDA)測定 | 支鏈氨基酸 BCAA檢測
引用文獻
Jia, Yali et al. (2017) Sonodynamic action of hypocrellin B triggers cell apoptoisis of breast cancer cells involving caspase pathway, Ultrasonics. 2017 Jan;73:154-161.
Karunakaran, Denuja et al. (2016) Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis Sci Adv. 2016 Jul 22;2(7):e1600224
Han et al., Caspase-Mediated Apoptosis in the Cochleae Contributes to the Early Onset of Hearing Loss in A/J Mice.ASN Neuro, Feb 2015; 7: 1759091415573985.
Robinson et al., Plasma Membrane Cholesterol as a Regulator of Human and Rodent P2X7 Receptor Activation and Sensitization. J. Biol. Chem., Nov 2014; 289: 31983 – 31994.
Wang et al., Farnesol induces apoptosis-like cell death in the pathogenic fungusAspergillus flavus. Mycologia, Sep 2014; 106: 881 – 888.
乾浴加熱水浴槽 | Finnpipette F3 微量分注器 | 試管振盪器 Vortex Mixer | Genereach迷你型微量離心機 | ELISA儀器