Hygromycin B  | 貨號2589 (ab286934)

An antibiotic and a selection agent

產品描述：Hygromycin B是由吸水鏈黴菌（Streptomyces hygroscopicus）產生的氨基糖苷類抗生素，其通常用作含有hph或hygHygromycin B抗性基因的細胞選擇劑。 Hygromycin B被認為通過加強核醣體受體（“A”）位點中肽基-tRNA的相互作用來抑制蛋白質合成，從而防止EF-2（延伸因子-2）的易位。Hygromycin B對大多數細菌，真菌和高等真核生物都有效。

Alternate Name	(3’R,3aS,4S,4’R,5’R,6R,6’R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6′-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2′-oxane]-3′,4′,5′,7-tetrol
Appearance	Off-white to light tan powder
CAS #	31282-04-9
Molecular Formula	C₂₀H₃₇N₃O₃
Molecular Weight	527.52
Purity	≥90% by HPLC
Solubility	H₂O (~ 50 mg/ml)
InChi Key	GRRNUXAQVGOGFE-KPBUCVLVSA-N
PubChem CID	35766
MDL Number	MFCD06795479
Handling	Protect from light and moisture
Storage Conditions	2-8ºC