Cycloheximide蛋白質合成抑制劑 | 貨號1041-1G
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Cycloheximide蛋白質合成抑制劑 | 貨號1041-1G
A protein synthesis inhibitor
產品介紹: 對抗許多酵母(yeasts)和真菌(fungi)抗生素。 干擾轉譯(translocation)步驟進而抑制真核生物中蛋白質的合成（不在原核生物中）。它通過作用於真核生物核醣體(eukaryote ribosome)的60S亞基(60S subunit)來抑制鏈起始以及鏈延伸(chain elongation)，直接與酶轉位酶(translocase)相互作用。 環己酰亞胺(Cycloheximide)用作抑制劑以研究真核生物中的無細胞蛋白質生物合成(cell-free protein biosynthesis)，並且還用於阻斷核醣體依賴性(ribosome-dependent)體內多肽合成。 它在多種細胞中誘導細胞凋亡(apoptosis)，但也可以通過其他藥物延遲或抑制細胞凋亡(apoptosis)。
| Alternate Name | 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A |
| Appearance | • Liquid • Solid |
| Formulation | • 1041-1 (100 mM in DMSO) • 1041-1G (Solid) • 1041-5G (Solid) |
| CAS # | 66-81-9 |
| Molecular Formula | C₁₅H₂₃NO₄ |
| Molecular Weight | 281.35 |
| Purity | >95% |
| SMILES | CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C |
| InChi | InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1 |
| InChi Key | YPHMISFOHDHNIV-FSZOTQKASA-N |
| PubChem CID | 6197 |
| MDL Number | MFCD00082346 |
| Handling | Protect from light and moisture |
引用文獻
Davydova et al., Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2). J. Biol. Chem., Oct 2014; 289: 30499 – 30510.
Hee-Jeong Jeong et al., Nonsense-Mediated mRNA Decay Factors, UPF1 and UPF3, Contribute to Plant Defense, Plant Cell Physiol., Dec 2011; 52: 2147 – 2156.
Muehlbauer, S. et al. Proteasome Inhibitors Prevent Caspase-1-Mediated Disease in Rodents Challenged with Anthrax Lethal Toxin. Am. J. Pathol., 2010; 177: 735-743.
