脂磷壁酸 (Lipoteichoic acid) | CAS# 56411-57-5 MCE貨號 HY-N9481
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MCE (MedChem Express) -脂磷壁酸 (Lipoteichoic acid)
MCE總部位於美國新澤西，提供種類齊全的化學及生化研究用產品，包括創新的生命科學試劑，reference compounds (標準化合物)，APIs (原料藥) 及Natural compounds (天然化合物)以提供實驗室或科學研究之用，MedChemExpress(MCE)產品50000+ 特異性抑制劑、化合物庫、重組蛋白，專注於信號通路和疾病研究領域。全球文獻廣泛引用，質控體系嚴格，品質100%。
脂磷壁酸 (Lipoteichoic acid) | CAS# 56411-57-5 MCE貨號 HY-N9481
脂磷壁酸(Lipoteichoic acid) 是一種口服有效的抗發炎( anti-inflammatory )和抗腫瘤藥物( antitumor agent)。脂磷壁酸(Lipoteichoic acid) 是革蘭氏陽性菌(Gram-positive bacteria)中的關鍵免疫分子，透過誘導 C3 和抑制 CD55 來活化補體系統。脂磷壁酸(Lipoteichoic acid) 透過 PI3K/Akt/mTOR 路徑調節巨噬細胞自噬作用。脂磷壁酸(Lipoteichoic acid) 可導緻小鼠肺損傷。脂磷壁酸(Lipoteichoic acid) 可抑制黑色素(melanin)的產生。
| Description |
Lipoteichoic acid is an orally effect anti-inflammatory and antitumor agent. Lipoteichoic acid is a crucial immune molecule in Gram-positive bacteria that activates the complement system by inducing C3 and inhibiting CD55. Lipoteichoic acid regulates macrophage autophagy through the PI3K/Akt/mTOR pathway. Lipoteichoic acid induces lung damage in mice. Lipoteichoic acid inhibits the production of melanin[1][2][3][4][5][6][7]. |
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| In Vitro |
Lipoteichoic acid (0.1-20 μg/mL; 12-48 h) induces macrophage autophagy by inhibiting PI3K/AKT/mTOR pathway[2].
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[1]. Bong Jun Jung, et al. Lipoteichoic Acid from Staphylococcus aureus Activates the Complement System via C3 Induction and CD55 Inhibition. Microorganisms. 2021 May 24;9(6):1135. [Content Brief]
[2]. Lin D, et al. Enterococcus faecalis lipoteichoic acid regulates macrophages autophagy via PI3K/Akt/mTOR pathway. Biochem Biophys Res Commun. 2018 Apr 15;498(4):1028-1036. [Content Brief]
[3]. Kim HR, et al. Lipoteichoic acid isolated from Lactobacillus plantarum inhibits melanogenesis in B16F10 mouse melanoma cells. Mol Cells. 2015;38(2):163-70. [Content Brief]
[4]. Pradhan D, et al. Postbiotic Lipoteichoic acid of probiotic Lactobacillus origin ameliorates inflammation in HT-29 cells and colitis mice. Int J Biol Macromol. 2023 May 1;236:123962. [Content Brief]
[5]. Weill FS, et al. Lipoteichoic acid from Lactobacillus rhamnosus GG as an oral photoprotective agent against UV-induced carcinogenesis. Br J Nutr. 2013 Feb 14;109(3):457-66. [Content Brief]
[6]. Zhang Y, et al Shikonin ameliorates lipoteichoic acid induced acute lung injury via promotion of neutrophil apoptosis. Mol Med Rep. 2021 Feb;23(2):133. [Content Brief]
[7]. Hara H, et al. The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell. 2018 Nov 29;175(6):1651-1664.e14. [Content Brief]
MedChemexpress (MCE) 產品
MCE (MedChemexpress) 總部位於美國新澤西，提供種類齊全的化學及生化研究用產品，包括創新的生命科學試劑，reference compounds (標準化合物)，APIs (原料藥) 及Natural compounds (天然化合物)以提供實驗室或科學研究之用，MedChemExpress(MCE)產品50000+ 特異性抑制劑、化合物庫、重組蛋白，專注於信號通路和疾病研究領域。全球文獻廣泛引用，質控體系嚴格，品質100%。官網連結 https://www.medchemexpress.com
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