MPTP hydrochloride MPTP鹽酸鹽 | CAS#23007-85-4 MCE貨號HY-15608
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MCE (MedChem Express) -MPTP 鹽酸鹽
MCE總部位於美國新澤西，提供種類齊全的化學及生化研究用產品，包括創新的生命科學試劑，reference compounds(標準化合物)，APIs(原料藥)及Natural compounds(天然化合物)以提供實驗室或科學研究之用，MedChemExpress(MCE)產品50000+ 特異性抑制劑、化合物庫、重組蛋白，專注於信號通路和疾病研究領域。全球文獻廣泛引用，質控體系嚴格，品質100%。
MPTP hydrochloride MPTP鹽酸鹽 | CAS#23007-85-4 MCE貨號HY-15608 Purity: ≥99.52%
MPTP 鹽酸鹽是一種腦部滲透性多巴胺神經毒素(brain penetrant dopamine neurotoxin)，可誘發巴金森氏症(Parkinson’s Disease)。 MPTP 鹽酸鹽(MPTP hydrochloride,)是 MPP+ 的前體，可誘導細胞凋亡(apoptosis)。MPTP鹽酸鹽可用於動物建模，建立帕金森氏症模型。MPTP的毒性作用可以透過單胺氧化酶抑制劑( monoamine oxidase inhibitor)在體內完全消除，並透過兒茶酚-O-甲基轉移酶( catechol-O-methyltransferase) 抑制劑增強[1]。在動物模型中，大多數受到 LPS 或 MPTP 損傷的大腦反應性星狀細胞中 Gas1 表現顯著升高[3]。
MPTP hydrochloride Chemical Structure
CAS No. : 23007-85-4
| Molecular Weight |
209.72 |
|---|---|
| Appearance |
Solid |
| Formula |
C12H16ClN |
| CAS No. | |
| SMILES |
CN1CC=C(C2=CC=CC=C2)CC1.[H]Cl |
| Shipping |
Room temperature in continental US; may vary elsewhere. |
| Storage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture) |
27 Publications Citing Use of MCE MPTP hydrochloride
MPTP hydrochloride purchased from MedChemExpress. Usage Cited in: Brain Res. 2019 Jul 15;1715:203-212. [Abstract]
Immunofluorescence for TH. The intranigral Apelin-13 injection significantly inhibits MPTP-induced the neurodegeneration of dopaminergic neurons in the SNpc.
MPTP hydrochloride purchased from MedChemExpress. Usage Cited in: Pharmacol Biochem Behav. 2019 Feb;177:1-11. [Abstract]
Effect of treatment with Rapamycin, trehalose, or their combination on tyrosine hydroxylase (TH) expression in the striatum in MPTP-induced mouse model of Parkinson’s disease.
MPTP hydrochloride purchased from MedChemExpress. Usage Cited in: Pharmacol Biochem Behav. 2019 Feb;177:1-11. [Abstract]
Effect of treatment with Rapamycin, trehalose, or their combination on autophagy activity measured by quantified immunoreactivity of LC3-II in the s. nigra. MPTP is administered at the dose of 20 mg/kg (i.p., daily) for 4 days to induce PD-like pathology.
MPTP hydrochloride purchased from MedChemExpress. Usage Cited in: Brain Res. 2016 Jul 1;1642:546-552. [Abstract]
RNA 5hmC decreases in a MPTP-induced Parkinson’s disease mouse model. MPTP (i.p. 60 mg/kg) is injected to induce Parkinson’s disease model in mice. At 24 h after last MPTP injection, open field test is performed. After behavioral tests, the hippocampus (Hipo), the substantia nigra (SN), the striatum (Str), and the cortex (Ctx) are collected and total RNA is extracted. Total 100 ng RNA is used for dot blot analysis to detect 5hmC
MedChemexpress (MCE) 產品
MCE (MedChemexpress) 總部位於美國新澤西，提供種類齊全的化學及生化研究用產品，包括創新的生命科學試劑，reference compounds (標準化合物)，APIs (原料藥) 及Natural compounds (天然化合物)以提供實驗室或科學研究之用，MedChemExpress(MCE)產品50000+ 特異性抑制劑、化合物庫、重組蛋白，專注於信號通路和疾病研究領域。全球文獻廣泛引用，質控體系嚴格，品質100%。官網連結 https://www.medchemexpress.com
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