SCR7 | CAS#1533426-72-0 APExBIO 貨號A8705
代理廠牌: | |
原廠連結: | |
相關下載: |
雷帕黴菌(Rapamycin)| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑)
細胞反應(Cellular responses)由與特定受體結合的蛋白質(proteins)、藥物(drugs)或病原體(pathogens)觸發。受體介導(Receptor mediated signaling)的信號傳導是放大信號的酶促反應級聯。調節受體功能的激動劑(agonists)和拮抗劑(antagonists)是研究和醫療實踐的重要工具。
SCR7 | CAS#1533426-72-0 APExBIO 貨號A8705
DNA ligase IV inhibitor
Scr7 是一種 DNA 連接酶 IV 抑制劑(DNA ligase IV inhibitor),最初被確定為一種抗癌劑 (anti-cancer agent)。Scr7 靶向 DNA 連接酶 IV 的 DNA 結合域(DNA binding domain),降低其對雙鏈斷裂 (double strand breaks , DSB) 的親和力並抑制其功能。 Scr7 還抑制 DNA 連接酶 III(但不抑制 DNA 連接酶 I),儘管效率較低。用強力黴素處理細胞以誘導 Cas9 表達,用不同濃度的 Scr7 處理 24 小時。 Scr7 維持的細胞能夠進入 S/G2 期,這是 HDR 所必需的 [1]。用 Scr7 治療小鼠會影響淋巴細胞發育,因為 DNA 連接酶 IV(DNA ligase IV) 在通過 C-NHEJ16 進行 V(D)J 重組過程中編碼末端的連接中起關鍵作用。由於 Scr7 的非共價結合模式,Scr7 治療後淋巴細胞發育的缺陷是短暫的和可逆的。 Scr7 通過瞬時阻斷 NHEJ(依賴 DNA 連接酶 I 的 alt-NHEJ 除外)增強 HDR 的頻率,從而在培養細胞和小鼠中通過 CRISPR-Cas9 進行精確的基因組編輯(genome editing) [2]。
Storage | Store at -20°C |
M.Wt | 334.39 |
Cas No. | 1533426-72-0 |
Formula | C18H14N4OS |
Solubility | insoluble in H2O; ≥16.72 mg/mL in DMSO; ≥2.6 mg/mL in EtOH with ultrasonic |
Chemical Name | 5,6-bis((E)-benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one |
SDF | Download SDF |
Canonical SMILES | S=C(NC(/N=C/C1=CC=CC=C1)=C2/N=C/C3=CC=CC=C3)NC2=O |
Shipping Condition | Ship with blue ice, or upon other requests. |
General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon. |
APExBIO提供優質的胜肽和生物分析試劑,廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域, 還提供定制的服務,包括多肽合成,抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析,高效液相色譜,質譜,和HMNR數據。
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SCR7 | CAS#1533426-72-0 | 貨號A8705 | DNA ligase IV inhibitor |
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Potent MTH1 inhibitor |
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Proteases | Z-VAD-FMK | CAS# 187389-52-2 APExBIO | CAS# 187389-52-2 | 貨號 A1902 |
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品項 | CAS# | #貨號 | 應用 |
Romidepsin (FK228, depsipeptide) |
CAS#128517-07-7
|
貨號A8173 | HDAC1/HDAC2,強效和選擇性抑制劑 |
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貨號A8321
|
高效、廣譜的化療藥物 |
Azithromycin | CAS#83905-01-5 | 貨號A2213 | Hsp90 inhibitor |
Bleomycin Sulfate |
CAS# 9041-93-4
|
貨號B1398 | Antibiotic by inhibiting protein synthesis |
Nystatin (Fungicidin) | CAS#1400-61-9 | 貨號B1993 | antifungal antibiotic |
Rapamycin | CAS#53123-88-9 | 貨號A8167 | Original antifungal antibiotic |
Daptomycin | CAS#103060-53-3 | 貨號A1206 | Calcium-dependent antibiotic |
品項 | CAS# | #貨號 | 應用 |
Z-VAD-FMK | CAS# 187389-52-2 | 貨號 A1902 |
Proteases ICE-like proteases |
TAPI-1 | CAS#171235-71-5 | 貨號 B4686 |
Proteases TACE/ADAM17 inhibitor Product Citation+3 |
Talabostat mesylate | CAS# 150080-09-4 | 貨號B3941 |
Proteases DPP4 二肽基肽酶特異性抑制劑 |
Z-IETD-FMK | CAS# 210344-98-2 | 貨號B3232 | inhibitor of caspase 8 |
Cisplatin | CAS# 15663-27-1 | 貨號A8321 | 高效、廣譜的化療藥物 |
17-DMAG (Alvespimycin) HCl | CAS#467214-21-7 | 貨號A2213 | Hsp90 inhibitor |
CA-074 Me | CAS# 147859-80-1 | 貨號A8239 | Cathepsin B inhibitor |
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