Oxaliplatin | CAS#61825-94-3 APExBIO 貨號A8648
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DNA/RNA合成-細胞凋亡系列商品->>Oxaliplatin
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Oxaliplatin | CAS#61825-94-3 APExBIO 貨號A8648
Antitumor agent. Purity = 99.92%
Oxaliplatin主要通過符合 DNA 加合物來抑制 DNA 合成。Oxaliplatin是一種鉑化合物(platinum compounds)，具有廣譜的抗腫瘤活性(anti-tumor activity)，並且已證明與其他鉑化合物(platinum compounds)缺乏交叉耐藥性。Oxaliplatin誘導導致細胞凋亡(cell apoptosis)的原發性和繼發性 DNA 損傷。
體外：Oxaliplatin對人黑色素瘤細胞系(melanoma cell lines) C32 和 G361 具有活性，IC50 值分別為 0.98 mM 和 0.14 mM。Oxaliplatin有效抑制膀胱癌細胞系(bladder carcinoma cell lines) RT4 和 TCCSUP、卵巢癌細胞系 (ovarian carcinoma cell line )A2780、結腸癌細胞系 HT-29(colon carcinoma cell line)、膠質母細胞瘤細胞系(glioblastoma cell lines) U-87MG 和 U-373MG，以及黑色素瘤細胞系(melanoma cell lines) SK-MEL-2 和 HT-144 IC50 值分別為 11 μM、15 μM、0.17 μM、0.97 μM、17.6 μM、2.95 μM、30.9 μM 和 7.85 μM。
臨床試驗：在轉移性結直腸癌患者中，與氟尿嘧啶/亞葉酸聯用，Oxaliplatin作為一線治療和對先前化療無效的患者均顯示出對轉移性結直腸癌的活性。此外，Oxaliplatin在鉑類預處理的卵巢癌、非霍奇金淋巴瘤、乳腺癌、間皮瘤和非小細胞肺癌患者中也顯示出療效。
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 397.29 |
| Cas No. | 61825-94-3 |
| Formula | C8H14N2O4Pt |
| Solubility | insoluble in EtOH; ≥37.25 mg/mL in DMSO; ≥3.94 mg/mL in H2O with gentle warming |
| Chemical Name | (1R,2R)-cyclohexane-1,2-diamine;oxalate;platinum(2+) |
| SDF | Download SDF |
| Canonical SMILES | C1CCC(C(C1)N)N.C(=O)(C(=O)[O-])[O-].[Pt+2] |
| Shipping Condition | Ship with blue ice, or upon other requests. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon. |
- Qing Zhang, Yue Zhou, et al. “Low-dose orlistat promotes the therapeutic effect of oxaliplatin in colorectal cancer.” Biomed Pharmacother. 2022 Sep;153:113426. PMID: 36017794
- Xia Liao, Yaoyao Zhang, et al. “Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway.” J Cancer. 2021 Aug 24;12(20):6071-6080.PMID: 34539880
- Liao X, Song G, et al. “Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.” BMC Cancer. 2020;20(1):31.PMID: 31931755
- Feng M, Jin JQ, et al. “Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating T(reg) cells.” Sci Adv. 2019 May 8;5(5):eaau5240.PMID: 31086813
- Cho SY, Chae J, et al. “Unstable Genome and Transcriptome Dynamics during Tumor Metastasis Contribute to Therapeutic Heterogeneity in Colorectal Cancers.” Clin Cancer Res. 2019 Jan 22.PMID: 30670495
- Goodspeed A, Jean A, et al. “A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder Cancer.” Eur Urol. 2019 Feb;75(2):242-250.PMID: 30414698
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