泛艾霉素 (Pirarubicin) | CAS#72496-41-4 APExBIO貨號B2295
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泛艾霉素 (Pirarubicin) | CAS#72496-41-4 APExBIO貨號B2295
anthracycline anti-neoplastic doxorubicin
泛艾霉素(Tunicamycin) Pirarubicin is an analogue of the anthracycline anti-neoplastic doxorubicin. Intercalates into DNA and interacts with Topo II (topoisomerase II) and supressing DNA replication. Pirarubicin is an inhibitor of Topo II. 泛艾霉素(Tunicamycin)是蒽環類(anthracycline)抗腫瘤多柔比星(anti-neoplastic doxorubicin)的類似物。 嵌入 DNA 並與 Topo II（拓撲異構酶 II）相互作用並抑制 DNA 複製(supressing DNA replication)。 Pirarubicin 是 Topo II 的抑制劑。
- Krai Daowtak,Suchart Kothan,et al. “In vitro evaluation of P-glycoprotein functions in human neuroblastoma cell lines.” Journal of Associated Medical Sciences.Vol 51 No 2 (2018): May-August.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 627.64 |
| Cas No. | 72496-41-4 |
| Formula | C32H37NO12 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥7.65 mg/mL in DMSO |
| Chemical Name | 7-[4-amino-6-methyl-5-(oxan-2-yloxy)oxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione |
| SDF | Download SDF |
| Canonical SMILES | CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)OC6CCCCO6 |
| Shipping Condition | Ship with blue ice, or upon other requests. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon. |
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