BMN-673 (Talazoparib) (PARP抑制劑) | CAS # 1207456-01-6貨號B1861

A potent and selective PARP1/2 inhibitor

產品介紹: BMN-673 (Talazoparib)是一種有效的選擇性PARP1 / 2抑制劑(PARP1/2 inhibitor)，Ki值分別為1.2和0.9 nM。它對72種受體 (72 receptors)，離子通道(ion channels)和酶(enzymes)的組成沒有影響。 BMN-673顯示出選擇性的抗腫瘤細胞毒性(antitumor cytotoxicity)，並以比早先的PARP1 / 2抑制劑(PARP1/2 inhibitors)低得多的濃度引發DNA修復生物標誌物(DNA repair biomarkers)。

Alternate Name	(8R,9S)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-8,9-dihydro-1H-pyrido[4,3,2-de]phthalazin-3(2H)-one; Talazoparib
Appearance	Crystalline solid
CAS #	1207456-01-6
Molecular Formula	C₁₉H₁₄F₂N₆O
Molecular Weight	380.35
Purity	≥98% by HPLC
Solubility	DMSO (>15 mg/ml)
SMILES	CN1C(=NC=N1)C2C(N=C3C=C(C=C4C3=C2NNC4=O)F)C5=CC=C(C=C5)F
InChi	InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,25H,1H3,(H,26,28)
InChi Key	IUEWAGVJRJORLA-UHFFFAOYSA-N
PubChem CID	53345055
Handling	Protect from air and light
Storage Conditions	-20°C
Shipping Conditions	Gel Pack
USAGE	For Research Use Only! Not For Use in Humans.

Olaparib (PARP抑制劑) | Rucapar (PARP抑制劑) | Tosylate | Talazoparib | PARP1 (Human) ELISA Kit |BRCA1 抗體  |BRCA2 抗體