AG-014699 phosphate/ Rucapar (PARP抑制劑) | CAS#459868-92-9貨號2890
| 代理廠牌： |  |
| 原廠連結： | |
| 相關下載： |
特點
AG-014699 phosphate/ Rucapar (PARP抑制劑) | 貨號2890
A potent PARP1 inhibitor
產品介紹: AG-014699磷酸鹽 (AG-014699 phosphate)是一種有效的PARP1細胞滲透抑制劑(cell-permeable inhibitor)，Ki為1.4 nM。它選擇性地與PARP 1結合併抑制PARP1介導的DNA修復，從而增強了基因組的不穩定性和細胞凋亡。顯示抗腫瘤活性(antineoplastic activity)。
| Alternate Name | 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-4,5-dihydro-1H-azepino[5,4,3-cd]indol-6(3H)-one phosphate; Rucaparib; PF-01367338 |
| Appearance | Light yellow to yellow solid |
| CAS # | 459868-92-9 |
| Molecular Formula | C₁₉H₂₁FN₃O₅P |
| Molecular Weight | 421.36 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~20 mg/ml) |
| SMILES | CNCC1=CC=C(C=C1)C2=C3CCNC(=O)C4=CC(=CC(=C34)N2)F.OP(=O)(O)O |
| InChi | InChI=1S/C19H18FN3O.H3O4P/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-5(2,3)4/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);(H3,1,2,3,4) |
| InChi Key | FCCGJTKEKXUBFZ-UHFFFAOYSA-N |
| PubChem CID | 9931953 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
Olaparib (PARP抑制劑) | Rucapar (PARP抑制劑) | Tosylate | Talazoparib | PARP1 (Human) ELISA Kit |BRCA1 抗體 |BRCA2 抗體