MK-4827 (Tosylate) (PARP抑制劑) | CAS #1038915-73-9貨號B2003

A selective PARP-1 and PARP-2 inhibitor

產品介紹: MK-4827是一種有效的選擇性PARP-1和PARP-2抑制劑，IC 50值分別為3.8 nM和2.1 nM。它在臨床前腫瘤模型中BRCA和PTEN功能喪失。誘導合成致死性(synthetic lethality) 。

Alternate Name	(3S)-3-[4-[7-(Aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidine Tosylate; MK-4827 Tosylate; Niraparib tosylate
Appearance	Off-white to pale yellow solid
CAS #	1038915-73-9
Molecular Formula	C₁₉H₂₀N₄O •C₇H₈O₃S
Molecular Weight	492.6
Purity	≥98% by HPLC
Solubility	DMSO (~25 mg/ml)
SMILES	CC1=CC=C(C=C1)S(=O)(=O)O.C1CC(CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N
InChi	InChI=1S/C19H20N4O.C7H8O3S/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;1-6-2-4-7(5-3-6)11(8,9)10/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);2-5H,1H3,(H,8,9,10)/t14-;/m1./s1
InChi Key	LCPFHXWLJMNKNC-PFEQFJNWSA-N
PubChem CID	78357761
Handling	Protect from air and light
Storage Conditions	-20°C
Shipping Conditions	Gel Pack
USAGE	For Research Use Only! Not For Use in Humans.

Olaparib (PARP抑制劑) | Rucapar (PARP抑制劑) | Tosylate | Talazoparib | PARP1 (Human) ELISA Kit |BRCA1 抗體  |BRCA2 抗體