Olaparib/PARP抑制劑|CAS#763113-22-0 貨號1952
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Olaparib (PARP抑制劑) | CAS#763113-22-0 貨號1952
A highly potent and selective PARP-inhibitor
產品介紹: Olaparib為細胞可滲透(Cell-permeable)，一種高效且選擇性的PARP抑制劑 (selective PARP-inhibitor)，對於PARP-1和PARP-2，IC₅₀值分別為5 nM和1 nM。 Olaparib在缺乏BRCA-1的乳腺癌細胞中顯示出獨立的活性。
| Alternate Name | 4-(3-(4-(cycloprppanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(2H)-one; ADZ-2281; KU-59436 |
| Appearance | White to off-white solid |
| CAS # | 763113-22-0 |
| Molecular Formula | C₂₄H₂₃FN₄O₃ |
| Molecular Weight | 434.46 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~33 mg/ml) or EtOH (~ 1.7 mg/ml) |
| SMILES | C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F |
| InChi | InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30) |
| InChi Key | FDLYAMZZIXQODN-UHFFFAOYSA-N |
| PubChem CID | 23725625 |
| MDL Number | MFCD13185161 |
| Handling | Protect from light and air |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
Olaparib (PARP抑制劑) | Rucapar (PARP抑制劑) | Tosylate | Talazoparib | PARP1 (Human) ELISA Kit |BRCA1 抗體 |BRCA2 抗體