Vancomycin hydrochloride | CAS#1404-93-9 APExBIO 貨號B1223

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相關下載：	Vancomycin hydrochloride操作手冊 Apexbio型錄下載

特點

雷帕黴菌（Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑)

Vancomycin hydrochloride is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent.

Vancomycin hydrochloride | CAS#1404-93-9 APExBIO 貨號B1223

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	1485.72
Cas No.	1404-93-9
Formula	C₆₆H₇₆Cl₃N₉O₂₄
Solubility	≥55.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; ≥22.15 mg/mL in H2O
SDF	Download SDF
Shipping Condition	Ship with blue ice, or upon other requests.
General tips	For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

Animal models	C57BL/6 mice challenged with Clostridium difficile (C. difficile) strain VPI 10463
Dosage form	20 mg/kg Once daily by oral gavage for 5 days
Applications	Vancomycin treatment of infected mice was associated with improved clinical, diarrhea, and histopathology scores and survival during treatment. However, after discontinuation of the drug, clinical scores and histopathology were worse in treated mice than in untreated infected controls. Decreasing the duration of vancomycin treatment from 5 days to 1 day decreased recurrence and deaths in C. difficile infection.
Note	The technical data provided above is for reference only.
	References: 1. Warren CA, van Opstal EJ, Riggins MS, et al. Vancomycin treatment’s association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice. Antimicrobial Agents and Chemotherapy, 2013, 57(2): 689-696.

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