替比培南（Tebipenem） | CAS#161715-21-5 APExBIO 貨號 B4864
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APExBIO Technology LLC 品牌 ->>替比培南（Tebipenem）
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替比培南（Tebipenem） | CAS#161715-21-5 APExBIO 貨號 B4864
Purity = 99.30%
An orally available carbapenem antibiotic with broad-spectrum antibacterial activities For research use only. We do not sell to patients.
替比培南（Tebipenem）一種具有廣效抗菌活性的口服卡巴培南類抗生素( orally available carbapenem antibiotic)。替比培南（Tebipenem）是一種口服卡巴培南類抗生素。替比培南（Tebipenem）對多種細菌的臨床分離株（MIC50 ≤ 0.0039 ~ 8 µg/ml）均有效，包括耐甲氧西林(methicillin-resistant strains)的金黃色葡萄球菌（S. aureus）和表皮葡萄球菌（S. epidermidis），以及抗青黴素的肺炎鏈球菌（S. pneumonia）。替比培南（Tebipenem）還能以時間和濃度依賴性的方式抑制β-內醯胺酶(β-lactamase )。替比培南（Tebipenem）的衍生物替比培南匹戊酯（Tebipenem pivoxil）正在開發中，作為首個口服卡巴培南類抗生素，用於治療兒科患者抗藥性肺炎鏈球菌(drug-resistant S. pneumonia)引起的呼吸道(respiratory )和耳鼻咽喉感染(otolaryngological infections)。
參考文獻：
1. Hazra S, Xu H, Blanchard JS.替比培南是一種新型卡巴培南類抗生素，它是一種緩慢作用的底物，能夠抑制結核分枝桿菌產生的β-內醯胺酶。 《生物化學》，2014, 53(22): 3671-3678。
2. Fujimoto K, Takemoto K, Hatano K, 等。用於腸外和口服的新型卡巴培南類抗生素：2-芳基卡巴培南類藥物的體內外活性及其在實驗動物中的藥物動力學。 《抗菌劑與化學療法》，2013, 57(2): 697-707。
For scientific research use only and should not be used for diagnostic or medical purposes.
- Purity = 99.30%
- COA (Certificate Of Analysis)
- HPLC (Retest)
- NMR (Nuclear Magnetic Resonance)
- MSDS (Material Safety Data Sheet)
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 383.49 |
| Cas No. | 161715-21-5 |
| Formula | C16H21N3O4S2 |
| Solubility | insoluble in EtOH; ≥19.15 mg/mL in H2O with gentle warming; ≥24.9 mg/mL in DMSO |
| Chemical Name | (4R,5S,6S)-3-[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | CC1C2C(C(=O)N2C(=C1SC3CN(C3)C4=NCCS4)C(=O)O)C(C)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Animal experiment:[2] | |
| Animal models | A mouse model of penicillin-resistant S. pneumoniae infection |
| Dosage form |
0.32 ~ 3.2 mg/kg Administered intravenously thrice daily 1 day and 2 days after infection |
| Applications | Tebipenem dose-dependently decreased the number of colony forming units (CFUs) in the lungs of infected mice. |
| Note | The technical data provided above is for reference only. |
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References: 1. Hazra S, Xu H, Blanchard JS. Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosis. Biochemistry, 2014, 53(22): 3671-3678. 2. Fujimoto K, Takemoto K, Hatano K, et al. Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals. Antimicrobial Agents and Chemotherapy, 2013, 57(2): 697-707. |
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