Gap 27 | CAS#198284-64-9 APExBIO 貨號A1045
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間隙連接蛋白系列商品->>Gap 27
APExBIO Technology LLC 是一家領先的小分子抑制劑 (Small Molecule Inhibitors)/活化劑(Activators)、化合物庫( Compound Libraries)、胜肽(Peptides)、檢測試劑盒(Assay Kits)、螢光標記(Fluorescent Label)、酶(Enzymes)、修飾核苷酸(Modified Nucleotides)、mRNA 合成以及各種分子生物學工具的供應商。APExBIO提供廣泛的產品線，涵蓋 20 多個不同的研究領域，例如癌症(cancer)、免疫學(immunology)、神經科學(neurosciences)、細胞凋亡(apoptosis)和表觀遺傳學(epigenetics)等。公司總部位於美國德州休士頓USA (Houston, Texas)，致力於服務全球客戶。高度重視產品品質。所有產品均遵循嚴格的生產指南，並附有分析證書、HPLC、質譜(Mass Spectrum)和HMNR以及體外驗證(in vitro validation)。 APExBIO產品已被《Nature》、《Cell》和《Science》等眾多頂級同行評審期刊引用。>>更多APExBio商品
細胞反應(Cellular responses)由與特定受體結合的蛋白質(proteins)、藥物(drugs)或病原體(pathogens)觸發。受體介導(Receptor mediated signaling)的信號傳導是放大信號的酶促反應級聯。調節受體功能的激動劑(agonists)和拮抗劑(antagonists)是研究和醫療實踐的重要工具。
Gap 27 | CAS#198284-64-9 APExBIO 貨號A1045
Selective gap junction blocker.
連接蛋白(Connexins)或間隙連接(gap junctions)是結構相關的跨膜蛋白(structurally-related transmembrane proteins)家族。間隙連接(Gap junctions)包含允許離子和小分子在相鄰細胞之間通過的通道。這種細胞間通訊(intercellular communication)與細胞對細胞內信號分子的反應的協調有關。鈣(Calcium)和肌醇磷酸鹽(inositol phosphates)是可以通過間隙連接通道的第二信使。這種合成的連接蛋白模擬肽(connexin-mimetic peptide) Gap 27 用於評估間隙連接通訊(gap-junctional communication)對破骨細胞(osteoclastic bone)骨吸收(bone resorption)的貢獻。得出的結論是，間隙連接通訊對於適當的骨重塑(bone remodeling)是必要的。
- Fan J, Chen Y, et al. “Multi-walled carbon nanotubes induce IL-1β secretion by activating hemichannels-mediated ATP release in THP-1 macrophages.” Nanotoxicology. 2020;1-18.PMID:32538272
- Ni X, Li XZ, et al. “Increased expression and functionality of the gap junction in peripheral blood lymphocytes is associated with hypertension-mediated inflammation in spontaneously hypertensive rats.” Cell Mol Biol Lett. 2018 Aug 20;23:40.PMID:30151015
- HAI-CHAO ZHANG, ZHONG-SHUANG ZHANG, et al.”Connexin 43 in splenic lymphocytes is involved in the regulation of CD4+ CD25+ T lymphocyte proliferation and cytokine production in hypertensive inflammation.” INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2017 October 20.
- Ni X, Wang A, et al. “Up-regulation of gap junction in peripheral blood T lymphocytes contributes to the inflammatory response in essential hypertension.” PLoS One. 2017 Sep 14;12(9):e0184773.PMID:28910394
- 5. Koenen, Anna, et al. “Effects of renal denervation on renal pelvic contractions and connexin expression in rats.” Acta Physiologica (2015). PMID:26436542
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 1304.55 |
| Cas No. | 198284-64-9 |
| Formula | C60H101N15O17 |
| Synonyms | Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile |
| Solubility | insoluble in EtOH; ≥5 mg/mL in H2O; ≥65.25 mg/mL in DMSO |
| Chemical Name | Gap 27 |
| SDF | Download SDF |
| Canonical SMILES | CCC(C)C(C(=O)NC(C(C)CC)C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(C(C)CC)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)O)NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(CO)N |
| Shipping Condition | Ship with blue ice, or upon other requests. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon. |
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APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。
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| Z-VAD-FMK | CAS# 187389-52-2 | 貨號 A1902 |
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| TAPI-1 | CAS#171235-71-5 | 貨號 B4686 |
Proteases TACE/ADAM17 inhibitor Product Citation+3 |
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| Z-IETD-FMK | CAS# 210344-98-2 | 貨號B3232 | inhibitor of caspase 8 |
| Cisplatin | CAS# 15663-27-1 | 貨號A8321 | 高效、廣譜的化療藥物 |
| 17-DMAG (Alvespimycin) HCl | CAS#467214-21-7 | 貨號A2213 | Hsp90 inhibitor |
| CA-074 Me | CAS# 147859-80-1 | 貨號A8239 | Cathepsin B inhibitor |
| VX-765 | CAS# 273404-37-8 | 貨號A8238 | Caspase-1 inhibitor |