AZD-3759 | 貨號9609

A potent epidermal growth factor receptor (EGFR) inhibitor

產品介紹:AZD-3759是一種有效的表皮生長因子受體（epidermal growth factor receptor , EGFR）抑制劑，具有潛在的抗腫瘤活性。 AZD-3759結合併抑制EGFR以及某些EGFR突變形式的活性。這可以防止EGFR介導的信號傳導，並可能導致誘導細胞死亡和抑制EGFR過表達細胞中的腫瘤生長。 AZD-3759 is a potent epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. AZD-3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells.

Alternate Name	(R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate
Appearance	Crystalline solid
CAS #	1626387-80-1
Molecular Formula	C₂₂H₂₃ClFN₅O₃
Molecular Weight	459.9
Purity	≥98% by HPLC
Solubility	DMSO
SMILES	CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C
InChi	InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1
InChi Key	MXDSJQHFFDGFDK-CYBMUJFWSA-N
PubChem CID	78209992
Handling	Protect from air and light
Storage Conditions	-20°C
Shipping Conditions	Gel Pack

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