GDNF, rat recombinant | 貨號7157  

Promotes dopamine uptake and survival and morphological differentiation of midbrain neurons

產品介紹：GDNF是與Artemin，Neurturin和Persephin結構相關的二硫鍵連接的同型二聚體神經營養因子。 這些蛋白質屬於生長因子的半胱氨酸結超家族，其呈現穩定的二聚體蛋白質結構。 GDNF通過多組分受體系統發出信號，該系統由RET和四種GFRα（α1-α4）受體之一組成。 GDNF特異性地促進中腦神經元的多巴胺攝取和存活以及形態學分化。 使用帕金森病小鼠模型，GDNF已被證明可改善運動遲緩，僵硬和姿勢不穩定等疾病。 功能性大鼠GDNF配體是二硫鍵連接的同型二聚體，由稱為單體的兩條15.0kDa多肽鏈組成。 每個單體含有七個保守的半胱氨酸殘基，其中一個用於鏈間二硫鍵橋接，另一個參與分子內環形成，稱為半胱氨酸結構型。

 Dopamine多巴胺檢測K4219   | α-突觸核蛋白（SNCA）ELISA試劑盒K4261-100  | 單胺氧化酶活性（總MAO / MAO-A / MAO-B）檢測 |  Chlorpromazine多巴胺受體拮抗劑 | Thioridazine多巴胺受體拮抗劑| GDNF多巴胺攝取促進劑

Alternate Name	Glial-Derived Neurotrophic Factor, ATF-1
Gene Symbol	GDNF
Gene ID	25453
Accession #	Q07731
Source	E. coli.
Appearance	Lyophilized powder
Physical Form Description	Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium citrate.
Molecular Weight	15 kDa
Purity by SDS-PAGE	≥98%
Endotoxin Level	< 0.1 ng/μg of protein (<1EU/μg).
Biological Activity	Determined by its ability to stimulate the proliferation of rat C6 cells.
Reconstitution Instructions	Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carri