Tunicamycin | CAS#11089-65-9 APExBIO貨號B7417

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Tunicamycin | CAS#11089-65-9 APExBIO貨號B7417

antibiotic,inhibits GlcNAc phosphotransferase (GPT)

產品介紹

衣黴素（Tunicamycin, CAS#11089-65-9）是一種常用的抗生素，可作為蛋白質N-糖基化抑制劑( protein N-glycosylation)。其作用機制是透過阻斷UDP-N-乙醯氨基葡萄糖(UDP-N-acetylglucosamine )與聚異戊二烯醇磷酸(polyisoprenol phosphate)之間的初始轉移反應，從而阻止N-連接糖蛋白合成所必需的多萜醇焦磷酸-N-乙醯氨基葡萄糖中間體( N-acetylglucosamine intermediates)的形成。這種干擾會誘導受影響細胞的內質網（endoplasmic reticulum, ER）壓力。實驗表明，衣黴素能有效抑制脂多醣刺激的RAW264.7巨噬細胞的發炎反應，降低COX-2和iNOS等發炎介質的表達和釋放。此外，它還能調節小鼠腸道和肝臟組織中壓力相關基因的表達，使其在內質網壓力、糖基化途徑(glycosylation pathways)和發炎(inflammation)的研究中具有重要價值。

Tunicamycin (CAS 11089-65-9) is an antibiotic commonly utilized as an inhibitor of protein N-glycosylation. It acts by blocking the initial transfer reaction between UDP-N-acetylglucosamine and polyisoprenol phosphate, thus preventing formation of dolichol pyrophosphate N-acetylglucosamine intermediates essential for N-linked glycoprotein synthesis. This interference induces endoplasmic reticulum (ER) stress within affected cells. Experimentally, tunicamycin effectively suppresses inflammatory responses in RAW264.7 macrophages stimulated by lipopolysaccharide, reducing expression and release of inflammatory mediators such as COX-2 and iNOS. Additionally, it modulates stress-related gene expression in murine intestinal and hepatic tissues, making it valuable for studies of ER stress, glycosylation pathways, and inflammation.

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	844.95
Cas No.	11089-65-9
Formula	C₃₉H₆₄N₄O₁₆ (tunicamycin C, n=10)
Solubility	≥25 mg/mL in DMSO
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

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蛋白抑制劑/緩衝液成分

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