Bay 11-7821 (BAY 11-7082) | IKK 抑制劑 CAS# 19542-67-7 APExBIO 貨號A4210 (BV1867-10)
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雷帕黴菌（Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑)
Bay 11-7821 (BAY 11-7082) | CAS# 19542-67-7 APExBIO 貨號A4210
Product Citation+7
IKK 抑制劑
Bay 11-7821 (Bay 11-7082) 是一種 IKK 抑制劑，IC50 值為 10μM [1]。Bay 11-7821 抑制 TNFα 誘導的 IκB-α 磷酸化，從而抑制 NF-κB。這隨後導致抑制 TNFα 誘導的 E-選擇素(E-selectin)、VCAM-1 和 ICAM-1 的表面表達。據報導，Bay 11-7821 不會抑制整個 TNFα 誘導的磷酸化(phosphorylation)，而是選擇性地抑制 IκB-α 的磷酸化 [1]。實驗表明，Bay 11-7821 在有效 IKK 抑制濃度下具有劇毒。它可以在MM細胞中誘導細胞壞死。此外，Bay 11-7821 通過誘導 B 細胞淋巴瘤和白血病 T 細胞死亡被證明具有抗炎能力。據報導，它還能抑制巨噬細胞中的 NALP3 炎性體 [2, 3]。
- Can Liu, Qiu Peng, et al. ” Deficiency of Lactoferrin aggravates lipopolysaccharide-induced acute inflammation via recruitment macrophage in mice.” Biometals. 2022 Jun 1;1-14. PMID: 35650365
- Mingze Ma, Fengxian Shi, et al. “TGF-β promote epithelial-mesenchymal transition via NF-κB/NOX4/ROS signal pathway in lung cancer cells.” Mol Biol Rep. 2021 Mar;48(3):2365-2375.PMID: 33792826
- Liu Hui-heng, Wang Jun-sheng, et al. “LPS induced PCT production via TLR-4/NF-кB passway: it is the difference of G-/G+ bacteremia rats.” Cytokine. 2020 Oct 7;137:155317.PMID: 33039977
- Ma L, Jiang M, et al. “Cigarette and IL-17A synergistically induce bronchial epithelial-mesenchymal transition via activating IL-17R/NF-κB signaling.” BMC Pulm Med. 2020;20(1):26. Published 2020 Jan 30. PMID: 32000730
- Zhang X, Yan K, et al. “Cyclooxygenase 2 promotes proliferation and invasion in ovarian cancer cells via the PGE2/NF-κB pathway.” Cell Transplant. 2019 Dec 10:963689719890597.PMID: 31822119
- Wang Z, Chen J, et al. “cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.” J Clin Invest. 2019 Aug 13;130:4850-4862.PMID: 31408442
- MXinwei Feng, Junfeng Lu, et al. “Mycobacterium smegmatis Induces Neurite Outgrowth and Differentiation in an Autophagy-Independent Manner in PC12 and C17.2 Cells.” Front. Cell. Infect. Microbiol. 19 June 2018.
| Storage | Store at -20°C |
| M.Wt | 207.25 |
| Cas No. | 19542-67-7 |
| Formula | C10H9NO2S |
| Solubility | insoluble in H2O; ≥64 mg/mL in DMSO; ≥10.64 mg/mL in EtOH with gentle warming and ultrasonic |
| Chemical Name | (E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC=C(C=C1)S(=O)(=O)C=CC#N |
| Shipping Condition | Ship with blue ice, or upon other requests. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon. |
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APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。
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