Cisplatin | CAS# 15663-27-1 APExBIO 貨號A8321
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蛋白酶(Proteases)系列商品->>Cisplatin
APExBIO Technology LLC 是一家領先的小分子抑制劑 (Small Molecule Inhibitors)/活化劑(Activators)、化合物庫( Compound Libraries)、胜肽(Peptides)、檢測試劑盒(Assay Kits)、螢光標記(Fluorescent Label)、酶(Enzymes)、修飾核苷酸(Modified Nucleotides)、mRNA 合成以及各種分子生物學工具的供應商。APExBIO提供廣泛的產品線，涵蓋 20 多個不同的研究領域，例如癌症(cancer)、免疫學(immunology)、神經科學(neurosciences)、細胞凋亡(apoptosis)和表觀遺傳學(epigenetics)等。公司總部位於美國德州休士頓USA (Houston, Texas)，致力於服務全球客戶。高度重視產品品質。所有產品均遵循嚴格的生產指南，並附有分析證書、HPLC、質譜(Mass Spectrum)和HMNR以及體外驗證(in vitro validation)。 APExBIO產品已被《Nature》、《Cell》和《Science》等眾多頂級同行評審期刊引用。>>更多APExBio商品
蛋白酶(Proteases)也稱為肽酶(peptidases)或蛋白水解酶(proteolytic enzymes)，由大量催化肽鍵水解(hydrolysis)並隨後導致蛋白質底物(protein substrates)降解為氨基酸(amino acids)的酶組成。蛋白酶(Proteases)與多種人類疾病有關，包括癌症(cancer)、神經退行性疾病(neurodegenerative disorders)、炎症性疾病(inflammatory diseases)和心血管疾病(cardiovascular diseases)。因此，許多蛋白酶抑制劑【小分子(small molecules)和蛋白質】已被鑑定為阻斷蛋白酶的活性(proteases)。蛋白酶抑制劑可以根據它們通過兩種一般機制抑制的蛋白酶類別分為不同的類型，即不可逆的“捕獲(trapping)”反應和可逆(reversible)的緊密結合反應。蛋白酶抑制劑已被用作治療蛋白酶相關疾病的診斷劑(diagnostic)或治療劑(therapeutic agents)。
Cisplatin | CAS# 15663-27-1 APExBIO 貨號A8321
Product Citation+12
一種高效、廣譜的化療藥物[1]。
Cisplatin是一種具有一些副作用的抗癌劑(chemotherapeutic agent)。據信它通過幾種機制誘導細胞凋亡(apoptosis)。傳統的機制是Cisplatin進入細胞，與DNA鳥嘌呤鹼基(DNA guanine bases)相互作用，形成鏈間(inter-)或鏈內交聯(intra-strand chain cross-linking)，從而阻止DNA的複雜(replication)。這種形成還可以通過激活 p53 來誘導細胞凋亡(apoptosis)。還發現Cisplatin會導致 ROS 產生並增加脂質過氧化(lipid peroxidation)，從而導致細胞進入凋亡途徑(apoptotic pathway)。此外，Cisplatin通過半胱天冬酶依賴性途徑(caspase-dependent pathway)誘導細胞凋亡(apoptosis)。在耳蝸細胞(cochlear cells)中，Cisplatin治療導致 caspase-3 和 -9 增加，並引起耳蝸(cochlear damage)損傷副作用 [1]。
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| Physical Appearance | A solid |
| Storage | Store at RT It is recommended to store in the form of powder in the dark, the solution is very unstable (Prepare Solution fresh and use at room temperature), DMF is recommended, DMSO can inactivate Cisplatin’s activity. |
| M.Wt | 300.05 |
| Cas No. | 15663-27-1 |
| Formula | Cl2H6N2Pt |
| Synonyms | CDDP |
| Solubility | insoluble in EtOH; insoluble in H2O; ≥12.5 mg/mL in DMF |
| Chemical Name | azane;dichloroplatinum(2+) |
| SDF | Download SDF |
| Canonical SMILES | N.N.Cl[Pt+2]Cl |
| Shipping Condition | Ship with blue ice, or upon other requests. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon. |
APExBIO台灣代理商
APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。
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| Cisplatin | CAS# 15663-27-1 | 貨號A8321 | 高效、廣譜的化療藥物 |
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APExBIO台灣代理商: https://www.apexbt.com/
APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。
