Caspase-9 多株抗體 | 胱天蛋白酶-9 多株抗體Biovision貨號3409
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特點
胱天蛋白酶-9是胱天蛋白酶家族成員中最重要的胱天蛋白酶之一。 誘導凋亡後，線粒體釋放的細胞色素c與胱天蛋白酶原-9 / Apaf-1相關。 複合物通過D315自切割將procaspase-9轉化成大亞基（35kDa或17kDa）和小（10kDa）。 活化的半胱天冬酶-9還進一步切割其他胱天蛋白酶成員，包括胱天蛋白酶-3，其是導致凋亡中許多關鍵蛋白質的蛋白水解切割的蛋白酶之一。 除了自我切割之外，胱天蛋白酶-3在D330也可以在體內切割胱天蛋白酶原-9。 該過程作為陽性反饋以擴增胱天蛋白酶激活途徑中的凋亡信號。
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| Antibody Target | Caspase-9 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide surrounding amino acid 345 of mouse caspase-9 |
| Accession # | CAM23133 |
| Gene ID | 12371 |
| Appearance | Colorless liquid |
| Concentration | 0.2 mg/ml |
| Formulation | 100 µg (0.2 mg/ml) protein A purified rabbit anti-caspase-9 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal. |
| Purification | Affinity purified |
| Species Reactivity | Mouse, rat |
| Application | Western blot |
| Application & Usage | Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Mouse small intestine and rat kidney tissue lysates can be used as positive controls. The antibody detects 45 kDa procaspase-9, 35/37 kDa cleaved large frag |
| Handling | The antibody solution should be gently mixed before use. |
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