3-DG-Imidazolone（晚期糖基化終產物）單株抗體0.25 mg/ml | 貨號IMI043

於血液透析患者的腎組織、糖尿病患者的晶狀體白內障和外側硬化患者的運動神經元中，可以檢測到3-DG衍生的咪唑酮-AGE表現。該3-DG-derived imidazolone-AGE抗體適用於慢性疾病的研究，其中3-DG-衍生的咪唑酮-AGE的累積可能是致病的。蛋白質與葡萄糖的長期孵育通過Schiff鹼和Amadori重排產物導致形成晚期糖基化終產物（AGE）。最近使用抗AGE抗體的免疫學研究表明在（i）人晶狀體中存在AGE，（ii）患有糖尿病性腎病和慢性腎衰竭的患者的腎近端小管，（iii）動脈壁的動脈粥樣硬化病變，（iv）ß2-血管透析相關澱粉樣變性患者和（v）阿爾茨海默病患者腦組織中腕管澱粉樣蛋白原纖維沉積的微球蛋白。通過3-脫氧葡醣醛酮（3-DG）形成AGE存在非氧化途徑。 3-DG是Maillard reaction美拉德反應的中間產物，其通過與蛋白質的arginin residues精氨酸殘基反應形成咪唑酮。

產品介紹:3-DG-Imidazolone單株抗體3-DG-derived imidazolone-AGE Catalogue, 晚期糖基化終產物抗體 (Clone: JNH-27)，number: IMI043 。免疫原Immunogen為3-DG-derived Imidazolone-HSA 。經由Protein G affinity純化腹水。抗體保存液為50% Block Ace? (Casein-containing solution, Dainippon Co.) and 0.1% ProClin? (Rohm & Haas) as a preservative  抗體使用濃度Working Concentration (liquid conc.) app. 7 µg/ml (IHC(C, P)。二抗建議: We recommend the use of BIOLOGO’s Universal Staining System DAB (Art. No. DA005) or AEC (Art. No. AE005).

ode	Name	Clone
HYD001	25(OH)Vitamin D3-1-alpha-Hydroxylase
IMI043	3-DG-Imidazolone (Advanced Glycation End Product)	JNH-27
AC100	ACTH, Corticotrophin
ADD001	Addicsin, Mouse (-GTRAP3-18)
AF100	AFP, Alpha-Fetoprotein	A-013-01/F1-6P2A8-P2B9A9
AF500	AFP, Alpha-Fetoprotein	A-013-01/F1-6P2A8-P2B9A9
AGE1-010	AGE-1 Glucose modified	7C1
AGE3-010	AGE-3 Glycolaldehyde modified	9D8
AGE4-010	AGE-4 Methylglyoxal modifiied	14B5
AGE101-0.2	AGE, Advanced Glycation End Products
AGE102-0.2	AGE, Advanced Glycation End Products
AGE102-1.0	AGE, Advanced Glycation End Products
AGE612	AGE, Advanced Glycation End Products	6D12
AGE612HRP	AGE, Advanced Glycation End Products: HRPO	6D12
AGE612BIO	AGE, Advanced Glycation End Products:BIO	6D12