晚期糖基化終產物單株抗體|3-DG-Imidazolone exalpha貨號IMI043
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3-DG-Imidazolone（晚期糖基化終產物）0.25 mg/ml | 貨號IMI043
3-DG-derived imidazolone-AGE於血液透析患者的腎組織、糖尿病患者的晶狀體白內障和外側硬化患者的運動神經元中，可以檢測到3-DG衍生的咪唑酮-AGE表現。該3-DG-derived imidazolone-AGE抗體適用於慢性疾病的研究，其中3-DG-衍生的咪唑酮-AGE的累積可能是致病的。蛋白質與葡萄糖的長期孵育通過Schiff鹼和Amadori重排產物導致形成晚期糖基化終產物（AGE）。最近使用抗AGE抗體的免疫學研究表明在（i）人晶狀體中存在AGE，（ii）患有糖尿病性腎病和慢性腎衰竭的患者的腎近端小管，（iii）動脈壁的動脈粥樣硬化病變，（iv）ß2-血管透析相關澱粉樣變性患者和（v）阿爾茨海默病患者腦組織中腕管澱粉樣蛋白原纖維沉積的微球蛋白。通過3-脫氧葡醣醛酮（3-DG）形成AGE存在非氧化途徑。 3-DG是Maillard reaction美拉德反應的中間產物，其通過與蛋白質的arginin residues精氨酸殘基反應形成咪唑酮。
產品介紹:3-DG-Imidazolone單株抗體3-DG-derived imidazolone-AGE Catalogue, 晚期糖基化終產物抗體 (Clone: JNH-27)，number: IMI043 。免疫原Immunogen為3-DG-derived Imidazolone-HSA 。經由Protein G affinity純化腹水。抗體保存液為50% Block Ace? (Casein-containing solution, Dainippon Co.) and 0.1% ProClin? (Rohm & Haas) as a preservative 抗體使用濃度Working Concentration (liquid conc.) app. 7 µg/ml (IHC(C, P)。二抗建議: We recommend the use of BIOLOGO’s Universal Staining System DAB (Art. No. DA005) or AEC (Art. No. AE005).
| ode | Name | Clone |
| HYD001 | 25(OH)Vitamin D3-1-alpha-Hydroxylase | |
| IMI043 | 3-DG-Imidazolone (Advanced Glycation End Product) | JNH-27 |
| AC100 | ACTH, Corticotrophin | |
| ADD001 | Addicsin, Mouse (-GTRAP3-18) | |
| AF100 | AFP, Alpha-Fetoprotein | A-013-01/F1-6P2A8-P2B9A9 |
| AF500 | AFP, Alpha-Fetoprotein | A-013-01/F1-6P2A8-P2B9A9 |
| AGE1-010 | AGE-1 Glucose modified | 7C1 |
| AGE3-010 | AGE-3 Glycolaldehyde modified | 9D8 |
| AGE4-010 | AGE-4 Methylglyoxal modifiied | 14B5 |
| AGE101-0.2 | AGE, Advanced Glycation End Products | |
| AGE102-0.2 | AGE, Advanced Glycation End Products | |
| AGE102-1.0 | AGE, Advanced Glycation End Products | |
| AGE612 | AGE, Advanced Glycation End Products | 6D12 |
| AGE612HRP | AGE, Advanced Glycation End Products: HRPO | 6D12 |
| AGE612BIO | AGE, Advanced Glycation End Products:BIO | 6D12 |