TMP-153, ACAT Inhibitors抑制劑 | Biovision貨號: B1181-50
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ACAT Inhibitors抑制劑 | TMP-153 | 貨號: B1181-50
TMP-153 , selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT)
TMP-153是acyl-CoA ACAT的選擇性抑製劑：IC 50（5至10Nm）的IC 50。大鼠和倉鼠中，有效力抑制膽固醇酯化，並減少流入血漿中。TMP-153顯示出毒性朊病毒感染的神經元（ScGT1）細胞。它可能具有潛在增加ScGT1細胞caspase-3的活性和前列腺素E2的生產。
TMP-153 is a selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC₅₀ of 5 to 10 nM. It has potency to inhibit cholesterol esterification and reduces its influx into the plasma of rats and hamsters. TMP-153 is shown toxicity to prion infected neuronal (ScGT1) cells. It might have potential to increase caspase-3 activity and prostaglandin E2 production in ScGT1 Cells.
Molecular Formula: C₂₄H₁₈ClF₂N₃O
Molecular Weight: 437.88
Purity: ≥98% by TLC
Solubility: DMSO (~25 mg/ml)
| Catalog # | Product Name+ | Size |
| 9506-5 | Avasimibe | 5 mg |
| 9506-25 | Avasimibe | 25 mg |
| 2053-1 | Pellitorine | 1 mg |
| 2053-5 | Pellitorine | 5 mg |
| 2214-250 | Terpendole C | 250 µg |
| 2214-1000 | Terpendole C | 1 mg |
| B1181-10 | TMP-153 | 10 mg |
| B1181-50 | TMP-153 | 50 mg |
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