SRT1720 HCl | CAS#1001645-58-4 APExBIO貨號 A4180
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SIRT1 活化劑(SIRT1 activator)-SRT1720
SRT1720 HCl| CAS#1001645-58-4 APExBIO貨號 A4180
SIRT1 activator Purity: 99.52%
SRT1720是一種小分子化合物( small-molecule compound)，能夠在體外活化sirtuin亞型SIRT1。 SRT1720 作為 SIRT1 活化劑(SIRT1 activator)的活性比白藜蘆醇(resveratrol)更強。它以 Sirt1 和 PGC-1α 依賴性方式影響粒線體呼吸(mitochondrial respiration)。 SRT1720 已被證明可以增強胰島素敏感性( insulin sensitivity)並改善粒線體能力(mitochondrial capacity)和氧化代謝(oxidative metabolism)。使用 SRT1720 治療多發性骨髓瘤 (multiple myeloma, MM) 細胞，可抑制對傳統療法和硼替佐米療法(bortezomib therapies )抗藥性的 MM 細胞的生長並誘導細胞凋亡，而不會顯著影響正常細胞的活力。 SRT1720 能夠增強硼替佐米(bortezomib)或地塞米鬆(dexamethasone)的細胞毒性活性(cytotoxic activity )。 SRT1720的抗MM活性與：1) caspase-8、caspase-9、caspase-3、聚(ADP)核糖聚合酶的活化； 2）活性氧(reactive oxygen species)增加； 3) 誘導磷酸化共濟失調毛細血管擴張突變(phosphorylated ataxia telangiectasia mutated)/檢查點激酶2訊號傳導； 4) 血管內皮生長因子誘導的MM細胞遷移及相關血管新生減少； 5) 抑制核因子-κB。SRT1720 是一種 SIRT1 活化劑。與對照組相比，它使 VEGF 濃度增加了約 30%，表明 SRT1720 可能促進腫瘤的血管生成(angiogenesis of tumors)。SRT1720 並沒有顯著影響原發腫瘤的大小和重量，但使肺轉移急劇增加約 150%。
- 1. Jinan Elayyan, Idan Carmon, et al. “Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction.” Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2116855119. PMID: 35594394
- 2. Xueyu Hu, Gangning Feng, et al. “The Protective Mechanism of SIRT1 on Cartilage Through Regulation of LEF-1.” Research Square. doi.org/10.21203/rs.3.rs-214497/v1.
- 3. Yangyang Li, Lei Wang, et al. “SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway.” Pain Res Manag 2020 Aug 18;2020:4245968. PMID: 32922581
- 4. Li Y, Xi Y, et al. “Sirtuin 1 activation alleviates primary biliary cholangitis via the blocking of the NF-κB signaling pathway.” Int Immunopharmacol. 2020;83:106386. PMID: 32193100
- 5. Lin Y, Liu J, et al. “FADD Phosphorylation Modulates Blood Glucose Levels by Decreasing the Expression of Insulin-Degrading Enzyme.” Mol Cells. 2020;43(4):373-383. PMID: 32191993
- 6. Gao P, Li L, et al. “Activation of Transient Receptor Potential Channel Vanilloid 4 by DPP-4 (Dipeptidyl Peptidase-4) Inhibitor Vildagliptin Protects Against Diabetic Endothelial Dysfunction.” Hypertension. 2019 Nov 18:HYPERTENSIONAHA11913778. PMID: 31735085
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 506.02 |
| Cas No. | 1001645-58-4 |
| Formula | C25H23N7OS·HCl |
| Synonyms | SRT-1720,SRT 1720,SRT 1720 Hydrochloride |
| Solubility | ≥25.3 mg/mL in DMSO; insoluble in EtOH; ≥15.37 mg/mL in H2O with gentle warming and ultrasonic |
| Chemical Name | N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。
| Catalog | Sku | Name | CAS | Short Summary |
| A3821 | A3821-5 | SRT2104 (GSK2245840) | 1093403-33-8 | SIRT1 activator,selective |
| A3839 | A3839-50 | SRT3190 | 1204707-73-2 | CXCR2 ligand,SIRT1 activator |
| A4180 | A4180-5 | SRT1720 HCl | 1001645-58-4 | SIRT1 activator |
| A4182 | A4182-5.1 | Resveratrol | 501-36-0 | SIRT1 activator |