DiscoveryProbe™ 臨床和 FDA 批准的藥物庫| FDA Clinical & FDA approved Drug Library貨號 L1052
FDA 臨床和 FDA 批准的藥物庫系列商品->>FDA Clinical & FDA approved Drug Library
A collection of 2726 clinical & FDA approved drugs supplied as lyophilized powder or pre-dissolved DMSO solutions
APExBIO Technology LLC 是一家領先的小分子抑制劑(Small Molecule Inhibitors)/活化劑(Activators)、化合物庫( Compound Libraries)、胜肽(Peptides)、檢測試劑盒(Assay Kits)、螢光標記(Fluorescent Label)、酶(Enzymes)、修飾核苷酸(Modified Nucleotides)、mRNA 合成以及各種分子生物學工具的供應商。APExBIO提供廣泛的產品線，涵蓋 20 多個不同的研究領域，例如癌症(cancer)、免疫學(immunology)、神經科學(neurosciences)、細胞凋亡(apoptosis)和表觀遺傳學(epigenetics)等。公司總部位於美國德州休士頓USA (Houston, Texas)，致力於服務全球客戶。高度重視產品品質。所有產品均遵循嚴格的生產指南，並附有分析證書、HPLC、質譜(Mass Spectrum)和HMNR以及體外驗證(in vitro validation)。 APExBIO產品已被《Nature》、《Cell》和《Science》等眾多頂級同行評審期刊引用。>>更多APExBio商品
FDA Clinical & FDA approved Drug Library APExBIO 貨號 L1052
FDA 臨床和 FDA 批准的藥物庫 (FDA Clinical & FDA approved Drug Library)
A collection of 2726 clinical & FDA approved drugs supplied as lyophilized powder or pre-dissolved DMSO solutions
DiscoveryProbe™ FDA 批准的藥物庫(drug library)包括 2320 種 FDA 批准的用於高通量篩選 (high throughput screening ,HTS) 和高內涵篩選 (high content screening ,HCS) 的藥物。它可以用來為舊藥尋找新靶點。這些藥物的生物活性和安全性已通過臨床試驗得到證實。由於都是FDA批准的藥物，篩選出來的藥物可以直接用於臨床試驗。
| Catalog No. | Product Name | Summary | Targets | CAS Number |
| A1229 | Lansoprazole | H+,K+-ATPase inhibitor | Membrane Transporter/Ion Channel|Proton Pump | 103577-45-3 |
| A1903 | E 64d | Cysteine protease inhibitor | Proteases|Cathepsin | 88321-09-9 |
| A2149 | Bosutinib (SKI-606) | Potent Abl/Src kinases | TGF-β / Smad Signaling|Bcr-Abl | 380843-75-4 |
| A2574 | Aprotinin | Inhibitor of bovine pancreatic trypsin | Proteases|Serine Protease | 9087-70-1 |
| A3021 | GDC-0449 (Vismodegib) | Hedgehog antagonist,potent and selective | Stem Cell|Hedgehog | 879085-55-9 |
| A8701 | Mesoridazine Besylate | Phenothiazine dopamine receptor anatagonist | Others|Others | 32672-69-8 |
| B1846 | Taurine | Glycine receptor agonist | Others|Others | 107-35-7 |
| C4910 | Spermine | Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site | Neuroscience|NMDA | 71-44-3 |
| Catalog No. | Product Name | Summary | Targets | CAS Number |
| A3298 | Cetirizine | Antihistamine | Neuroscience|Histamine Receptor | 83881-51-0 |
| A3789 | Salmeterol xinafoate | β2-adrenergic receptor agonist | GPCR/G protein|Adrenergic Receptor | 94749-08-3 |
| A4363 | Fluvastatin Sodium | HMG-CoA reductase inhibitor | Metabolism|HMG-CoA Reductase | 93957-55-2 |
| A4370 | Moclobemide (Ro 111163) | Reversible inhibitor of MAO-A | Metabolism|MAO | 71320-77-9 |
| A8252 | Nintedanib(BIBF 1120) | VEGFR/PDGFR/FGFR inhibitor | Tyrosine Kinase/Adaptors|PDGFR | 928326-83-4 |
| B1792 | Montelukast Sodium | Leukotriene receptor antagonist | GPCR/G protein|CysLT1 receptor | 151767-02-1 |
| N1674 | Piperine | MAPK inhibitor | Natural Products | 94-62-2 |
| N1707 | Coumarin | Precursor in chemical reaction | Natural Products | 91-64-5 |
James M. Havrilla, Cong Liu, et al. “PhenCards: a data resource linking human phenotype information to biomedical knowledge.” Genome Med. 2021 May 25;13(1):91.PMID:34034817
- Gur D, Chitlaru T, Mamroud E, et al. “Screening of an FDA-Approved Library for Novel Drugs against Y. pestis.” Antibiotics (Basel). 2021 Jan 3;10(1):40.PMID:33401634
- Moore JA, Meakin M, et al. “Effects of Caspofungin, Tolcapone, and Other FDA-Approved Medications on MRSA Susceptibility to Vancomycin.” J Glob Antimicrob Resist. 2020;S2213-7165(20)30078-3.PMID:32247076
- Turner TH, Alzubi MA, et al. “Identification of synergistic drug combinations using breast cancer patient-derived xenografts.” Sci Rep. 2020 Jan 30;10(1):1493.PMID:32001757
- Yang JJ, Han Y, et al. “Streamlined MRM method transfer between instruments assisted with HRMS matching and retention-time prediction.” Anal Chim Acta. 2020;1100:88–96.PMID:31987156
DiscoveryProbe Drug Library系列產品
生物活性篩選庫(Bioactive Screening Libraries)是即用型化學庫(chemical libraries)，用於藥物發現(drug discovery)、實驗室藥物篩選(lab drug screening)、藥物靶標識別(drug target identification)和其他製藥相關應用(pharmaceutical-related applications)。它們可用於高通量篩選 (high-throughput screening , HTS) 和高內涵篩選 (high-content screening , HCS)。
libraries包含超過 5,000 個具有經過驗證的生物學(validated biological)和藥理學活性(pharmacological activities)的小分子(small molecules)。還證明了化合物的溶解性(solubility)、純度(purity)和穩定性(stability)。這些化合物的安全性和有效性已通過文獻(literature)、臨床前(preclinical)和臨床研究(clinical research)得到證明，許多化合物已獲得 FDA 批准(FDA-approved)。
獨特小分子的集合，包括抑制劑(inhibitors)、拮抗劑(antagonists)和激動劑(agonists)。這些化合物專注於數百個目標，這些目標是 20 多個信號通路(signaling pathways)或研究領域(research areas)的一部分，包括 DNA 損傷(DNA Damage )/DNA 修復(DNA Repair)、細胞週期(Cell Cycle )/檢查點(Checkpoint)、JAK/STAT 信號通路(Signaling Pathway)、MAPK 信號通路(MAPK Signaling Pathway)、GPCR/G 蛋白(GPCR/G protein)、血管生成(Angiogenesis)、免疫學/炎症(Immunology/Inflammation )、內分泌學和激素(Endocrinology and Hormones)、癌症生物學(Cancer Biology)、新陳代謝(Metabolism)、幹細胞(Stem Cell)等。
提供定制的生物活性篩選庫(customized bioactive screening libraries)，您可以在庫中選擇所需的化合物、大小、數量、形式（粉末或溶液）和plate。
APExBIO提供優質的胜肽和生物分析試劑，廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域， 還提供定制的服務，包括多肽合成，抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析，高效液相色譜，質譜，和HMNR數據。
| Apexbio (產品貨號) |
Apexbio 產品品項 |
反應次數 |
Apexbio 產品介紹 (有連結) |
| K2249 | MTT細胞增殖檢測試劑盒 | 500T/2500T | 操作手冊 |
| K2262 | 中性紅血球增殖檢測試劑盒 | 500T | 操作手冊 |
| K2265 | 氫過氧化脂質 (LPO) 檢測試劑盒 | 100T | 操作手冊 |
| K2245 | 孔雀石綠磷酸鹽測定試劑盒 | 2500T | 操作手冊 |
| K2212 | 2-NBDG葡萄糖攝取檢測試劑盒 | 500T | 操作手冊 |
| K2293 | Annexin V-APC Reagent | 100T/200T | 操作手冊 |
| K4630 | GSH 和 GSSG 檢測試劑盒 | 100T | 操作手冊 |
