鏈脲佐菌素STZ(Streptozocin STZ) | CAS#18883-66-4貨號GC301002-100mg
Biochemical Reagents>Antibiotics系列產品-鏈脲佐菌素STZ
鏈脲佐菌素STZ(Streptozocin STZ) | CAS#18883-66-4 貨號GC301002-100mg
產品介紹:
本品為硝脲類抗生素(nitlurea antibiotic)，主要用於胰島細胞癌(pancreatic islet cell carcinoma)（β細胞或非β細胞癌）。對類癌(carcinoid tumor)、何杰金氏病(Hodgkin’s disease)、結腸癌(colon cancer)、肝癌(liver cancer)等有一定療效。它是一種有效的 HL60、K562 和 C1498 細胞 DNA 甲基化試劑(DNA methylation reagent )，IC50 值分別為 11.7、904 和 1024μg/mL。該實驗室通常用於複製糖尿病模型(diabetes models)。
本品為Stre公司生產的硝基脲類抗生素(nitrourea antibiotic )。 Achromogenes Uar.128。它與脂溶性亞硝酸鹽(fat-soluble nitrite)的不同之處在於，它的氯乙端是甲基，分子的另一端是氨基糖。 STZ能分解活性正甲基碳離子，與DNA形成鏈間交聯，使DNA鹼化。但STZ的烷基化作用(alkylation)比其他硝脲類藥物弱，而其代謝物甲基硝脲的烷基化作用比STZ強3~4倍。 STZ在體內可形成異氰酸酯。因此，它與核酸蛋白結合，抑制DNA聚合酶的活性，使受損的DNA難以修復。在抗腫瘤研究過程中，發現STZ可以使小鼠血糖升高，並導致狗和猴子患糖尿病，而且是永久性的。 STZ的糖尿病作用針對不同物種，不會引起豚鼠和人類糖尿病。糖尿病的發病機轉主要是由於胰島細胞內菸鹼醯胺腺嘌呤（DNA）含量減少所致。 STZ分子中的葡萄糖鹼基可使STZ進入胰島β細胞，引起β細胞核的形態變化，使其染色體凝集( chromosomes agglutinate)、伸長(elongate)、濃縮(concentrate)。
| Name | Streptozocin STZ |
| Synonym | Streptozotocin |
| CAS | 18883-66-4 |
| Molecular formula | C8H15N3O7 |
| Molecular mass | 265.22 |
| Purity | ≥98.0% |
| Appearance (character) | White to light yellow powder |
| Storage conditions | -20℃ |
| Unit | Bottle |
| Pubchem CID | 29327 |
| MDL No. | MFCD00006607 |
| EC No. | 242-646-8 |
| Related categories | Biochemical reagents, antibiotics |
| Solubility | 10mg / mL citric acid buffer ( pH4.2-4.5 ) |
| Validity | 24 months |
Instruction
A diabetes model was used as an example to illustrate the use of STZ. 1. Preparation of citric acid buffer liquid A: 2.1 g of citric acid (MW:210.14) was weighed and added into 100 mL of double steaming water to prepare liquid A; Liquid B: sodium citrate (MW:294.10) 2.94g was added to 100 mL of double steaming water to form liquid B. Mix A and B at a certain ratio (1:1.32 or 1:1), measure the pH value, adjust the pH in the range of 4.2-4.5, that is, the citric acid buffer needed to prepare STZ. 2. Before preparing STZ injection, place STZ in a dry and sterilized bottle, wrap it with tin foil, put it in an ice bath with citric acid buffer, and bring it to the animal room for later using. 3. The rats prepared for injection were weighed after overnight fasting. The rats were grouped so that STZ could be dissolved according to the group. 1% STZ injection was prepared with citrate buffer according to fasting body weight. If the subsequent injection operation is not skilled, do not dissolve the STZ at one time. Note: STZ is easy to deactivate, STZ is still required to be dry and avoid light after quick weighing, and dry aluminum foil (or tin foil) paper is recommended. 4. Intraperitoneal injection or tail vein injection. If the injection operation technique is not skilled, the two groups should be injected alternately and the injection should be completed within 30 minutes. Note: Most injections require a quick injection.
Note
STZ is unstable under moisture. If it needs to be weighed several times, it should be operated and stored in strict accordance with the principle of avoiding moisture. The operating environment, containers, and packing tools must be kept dry.
Long exposure should be avoided to prevent moisture. It expires after 30 minutes of damp exposure. This is for the same reason that modeling requires rapid injection because the aqueous solution is unstable.
The injection was prepared only before injection because the aqueous solution of STZ was extremely unstable.
For your safety and health, please wear lab coat and disposable gloves.
|
GC301002-100mg
|
Streptozocin STZ
鏈脲佐菌素STZ(Streptozocin STZ) | |
100 mg
|
|
GC301002-1g
|
Streptozocin STZ
鏈脲佐菌素STZ(Streptozocin STZ) | |
1 g
|
|
GC301003-1g
|
Penicillin G Sodium Salt
青黴素G鈉鹽(Penicillin G Sodium Salt) |
1 g
|
|
GC301004-1g
|
Ampicillin, Sodium Salt
氨芐西林鈉鹽(安比西林) (Ampicillin, Sodium Salt) |
1 g
|
|
GC301005-5g
|
Streptomycin Sulfate
硫酸鏈黴素(Streptomycin Sulfate) |
5 g
|
|
GC301008-1g
|
Kanamycin
卡那黴素(Kanamycin) |
1 g
|
|
GC301008-5g
|
Kanamycin
卡那黴素(Kanamycin) |
5 g
|
|
GC301009-1g
|
Hygromycin B
潮黴素B(Hygromycin B) |
1 g
|
|
GC301011-1g
|
G-418 Sulfate
G-418硫酸鹽(G-418 Sulfate) |
1 g
|
|
GC301013-100mg
|
Mupirocin
莫匹羅星(Mupirocin) |
100 mg
|
|
GC301014-5g
|
Norfloxacin
諾氟沙星(Norfloxacin) |
5 g
|
|
GC301016-100mg
|
Cisplatin
順鉑(Cisplatin) |
100 mg
|
|
GC301017-100mg
|
Rapamycin
雷帕黴素(Rapamycin) |
100 mg
|
|
GC301018-5g
|
Chloramphenicol
氯黴素(Chloramphenicol) |
5 g
|
Servicebio台灣品牌介紹-BRAND/AGENCY/品牌介紹- Servicebio
| Classfication | Cat No. | Name | Place of Origin | Spec. |
|
Amino Acids
|
GC304002 | L-Glutamine | 產品資料 | 100 g |
| GC304003 | L-Arginine hydrochloride | 產品資料 | 25 g | |
| GC304004-100g | L-Glutamine acid | 產品資料 | 100 g | |
| GC304005 | L-Isoleucine | 產品資料 | 25 g | |
| GC304006-25g | L-Leucine | 產品資料 | 25 g | |
| GC304007 | L-Lysine hydrochloride | 產品資料 | 25 g | |
| GC304009 | L-Methionine | 產品資料 | 25 g | |
| GC304010 | L-Phenylalanine | 產品資料 | 10 g | |
| GC304011-25g | L-Alanine | 產品資料 | 25 g | |
| GC304012 | L-Histidine | 產品資料 | 25 g | |
| GC304013 | L-Serine | 產品資料 | 25 g | |
| GC304014 | L-tryptophan | 產品資料 | 5 g | |
| GC304016 | L-Threonine | 產品資料 | 25 g | |
| GC304017 | L-Valine | 產品資料 | 10 g | |
| GC304019 | Glycine | 產品資料 | 500 g | |
| GC304021 | L-Histidine hydrochloride monohydrate | 產品資料 | 25 g | |
| GC304022 | Glycine cell culture grade 甘氨酸Glycine (細胞培養等級 |
產品資料 | 100 g | |
|
Protein Derivatives
|
GC305002-5g | Iodoacetamide | 產品資料 | 5 g |
| GC305003 | Trypsin 1:250 Source: Porcine Pancreas | 產品資料 | 10 g | |
| GC305004-5g | Pepsin 1:3000 | 產品資料 | 5 g | |
| GC305005 | Horseradish peroxidase | 產品資料 | 1 g | |
| GC305006 | Bovine Serum Albumin – import | 產品資料 | 100 g | |
| GC305009 | Human Albumin-FITC | 產品資料 | 0.5 mL | |
| GC305010 | Bovine Serum Albumin BSA | 產品資料 | 100 g | |
| GC305010-25G | Bovine Serum Albumin BSA | 產品資料 | 25 g | |
| GC305010-50G | Bovine Serum Albumin BSA | 產品資料 | 50 g | |
| GC305010-5G | Bovine Serum Albumin BSA | 產品資料 | 5 g | |
| GC305013-100mg | Collagenase I | 產品資料 | 100 mg | |
| GC305014-100mg | Collagenase II | 產品資料 | 100 mg | |
| GC305015-100mg | Collagenase IV 膠原酶IV (Collagenase IV) |
產品資料 | 100 mg | |
| GC305016-100g | Gelatine | 產品資料 | 100 g | |
|
Hormones
|
GC302002-25mg | Abscisic acid | 產品資料 | 25 mg |
| GC302003 | Angiotensin II | 產品資料 | 10 mg | |
|
Biological pigments
|
GC307002-25g | Crystal violet | 產品資料 | 25 g |
| GC307003-5g | Trypan Blue | 產品資料 | 5 g | |
| GC307005 | Alcian Blue8GX | 產品資料 | 1 g | |
| GC307006-5g | Bromphenol Blue | 產品資料 | 5 g | |
| GC307007 | Serva blue G-250 | 產品資料 | 10 g | |
| GC307008-5g | Congo Red | 產品資料 | 5 g | |
| GC307009-25g | Alizarin Red S | 產品資料 | 25 g | |
| GC307010-1g | Giemsa′s Stain | 產品資料 | 1 g | |
| GC307011 | Fuchsin basic | 產品資料 | 5 g | |
| GC307012-10g | Ponceau S | 產品資料 | 10 g | |
| GC307013 | Acid red 26 2R | 產品資料 | 5 g | |
| GC307014 | Direct Red 80 | 產品資料 | 5 g | |
| GC307015-5g | Sudan Black B | 產品資料 | 5 g | |
| GC307017 | Aniline blue | 產品資料 | 5 g | |
| GC307018 | Nuclear fast red | 產品資料 | 5 g | |
| GC307019 | Solvent Blue 38 | 產品資料 | 5 g | |
| GC307020 | Hematoxylin | 產品資料 | 5 g | |
| GC307021 | Solvent Red 43 | 產品資料 | 10 g | |
| GC307022 | Eosin Y, water soluble | 產品資料 | 10 g | |
| GC307023 | Safranin O | 產品資料 | 10 g | |
| GC307024 | Fast Green | 產品資料 | 10 g | |
| GC307026-5g | Pyronin G | 產品資料 | 5 g | |
| GC307027-1g | Janus Green B | 產品資料 | 1 g | |
| GC307030-10g | Brilliant Cresyl Blue | 產品資料 | 10 g | |
| GC307031 | Coomassie brilliant blue R-250 | 產品資料 | 5 g | |
| GC307034-1g | Thionine acetate | 產品資料 | 1 g | |
| GC307035-1g | Cresyl Fast Violet | 產品資料 | 1 g | |
| GC307036-1g | Orcein | 產品資料 | 1 g | |
| GC307037-1g | Carmine | 產品資料 | 1 g | |
| GC307039-10g | Mordant Blue 29 | 產品資料 | 10 g | |
| GC307042-5g | Oil Red O | 產品資料 | 5 g | |
| GC307045-25g | Rhodamine B | 產品資料 | 25 g | |
|
Vitamins
|
GC301015-25g | Vitamin C | 產品資料 | 25 g |
| GC303001 | Folic acid | 產品資料 | 5 g | |
| GC303004 | Ribofavin | 產品資料 | 25 g | |
| GC303005-5g | VitaminB6 | 產品資料 | 5 g | |
| GC303006-25g | VitaminB3 | 產品資料 | 25 g | |
| GC303008 | VitaminB12 | 產品資料 | 1 g | |
| GC303011-25mg | NADPH-Na4 | 產品資料 | 25 mg | |
| GC303013-250mg | β-nicotinamide adenine dinucleotide NAD | 產品資料 | 250 mg | |
| GC303014-250mg | NADH-Na2 | 產品資料 | 250 mg | |
|
Antibiotics
|
GC301002 | Streptozocin STZ | 產品資料 | 1 g |
| GC301002-100mg | Streptozocin STZ | 產品資料 | 100 mg | |
| GC301003 | Penicillin G Sodium salt | 產品資料 | 1 g | |
| GC301004 | Ampicillin | 產品資料 | 1 g | |
| GC301005 | Streptomycin sulfate | 產品資料 | 5 g | |
| GC301008 | Kanamycin | 產品資料 | 1 g | |
| GC301009 | Kanamycin sulfate | 產品資料 | 5 g | |
| GC301009-1g | Hygromycin B | 產品資料 | 1 g | |
| GC301011 | Geneticin G-418 | 產品資料 | 1 g | |
| GC301013 | Chloramphenicol | 產品資料 | 5 g | |
| GC301013-10mg | Pseudomonic acid | 產品資料 | 10 mg | |
| GC301014-5g | Norfloxacin | 產品資料 | 5 g | |
| GC301016 | Cisplatin | 產品資料 | 100 mg | |
| GC301017-100mg | Sirolimus | 產品資料 | 100 mg | |
|
Heterocyclic compounds
|
GC207001 | Imidazole | 產品資料 | 10 g |
| GC207002 | PMSF | 產品資料 | 5 g | |
| GC207003 | Freund’s Adjuvant Complete | 產品資料 | 10 mL | |
| GC207004 | Freund’s Adjuvant Incomplete | 產品資料 | 10 mL | |
|
Salt
|
GC201001 | Guanidine HCl | 產品資料 | 500 g |
| GC201002 | Guanidine thiocyanate | 產品資料 | 500 g | |
|
Sugar Alcohols
|
GC205001 | L(+)-Lactic acid | 產品資料 | 100 g |
| GC205002 | Pyruvic acid sodium salt | 產品資料 | 25 g | |
| GC205003 | D-Glucose, anhydrous | 產品資料 | 500 g | |
| GC205004-10g | D(+)-Trehalose dihydrate | 產品資料 | 10 g | |
| GC205005 | D(+)- Galactose | 產品資料 | 100 g | |
| GC205006-10g | D-(-)Arabinose | 產品資料 | 10 g | |
| GC205007-1g | DTE | 產品資料 | 1 g | |
| GC205008 | Glycerol | 產品資料 | 100 mL | |
| GC205009 | LPS | 產品資料 | 10 mg | |
| GC205010 | DTT | 產品資料 | 1 g | |
| GC205011 | IPTG | 產品資料 | 1 g | |
| GC205013 | Agarose | 產品資料 | 100 g | |
| GC205014 | Sucrose | 產品資料 | 500 g | |
| GC205015 | D-Sorbitol | 產品資料 | 500 g | |
|
Solvent
|
GC203001 | TEMED | 產品資料 | 100 mL |
| GC203002 | DMSO(Dimethyl sulfoxide) | 產品資料 | 100 mL | |
| GC203003 | Urea | 產品資料 | 500 g | |
| GC203005 | DMSO cellular level | 產品資料 | 10 mL | |
|
Complex
|
GC202001 | EDTA | 產品資料 | 500 g |
| GC202002 | EDTA -Na2 | 產品資料 | 500 g | |
|
Buffer salt
|
GC208001 | Tris (Hydroxymethyl) Aminomethane | 產品資料 | 500 g |
| GC208003 | RIS-HCL | 產品資料 | 500 g | |
| GC208004-100g | BIS-TRIS | 產品資料 | 100 g | |
| GC208006 | N-Tris[Hydroxymethyl]Methylglycine | 產品資料 | 100 g | |
| GC208007 | 4-propanesulfonyl morpholine | 產品資料 | 100 g | |
| GC208008-25g | HEPPS | 產品資料 | 25 g | |
| GC208009 | HEPES, Free acid | 產品資料 | 100 g | |
| GC208012-1g | TCEP·HCL | 產品資料 | 1 g | |
|
Surfactant
|
GC204001 | Tween-80 | 產品資料 | 100 mL |
| GC204002 | Tween-20 | 產品資料 | 100 mL | |
| GC204003 | Triton X-100 | 產品資料 | 100 mL | |
| GC204004 | Sodium dodecylsulfate | 產品資料 | 500 g | |
| GC204005 | Sodium dodecylsulfate | 產品資料 | 100 g | |
| GC204006 | Nonidet TM P40 Substitute NP-40 | 產品資料 | 100 g | |
| GC204007 | Deoxycholic acid， sodium salt | 產品資料 | 25 g | |
| GC204009-100ml | APES | 產品資料 | 100 mL | |
|
Amine organics
|
GC206002 | Acrylamide | 產品資料 | 500 g |
| GC206003 | N’-MBA | 產品資料 | 100 g | |
|
Polymer
|
GC209002-250g | PEG 8000 | 產品資料 | 250 g |
| GC209003-250g | PEG 6000 | 產品資料 | 250 g | |
| GC209004-100g | PEG 3350 | 產品資料 | 100 g | |
| GC209005-500g | Poly(ethylene glycol)2000 | 產品資料 | 500 g | |
| GC209006-250g | Poly(ethylene glycol) 20000 | 產品資料 | 250 g | |
|
Inorganic salt
|
GC106001 | Orthoboric acid | 產品資料 | 500 g |
| GC104004 | Sodium bicarbonate | 產品資料 | 500 g | |
| GC108003 | Citric acid monohydrate | 產品資料 | 100 g | |
| GC108004 | Sodium citrate dihydrate | 產品資料 | 100 g | |
| GC102001 | Calcium chloride | 產品資料 | 100 g | |
| GC102002 | Magnesium chloride hexahydrate | 產品資料 | 100 g | |
| GC102003 | Potassium chloride | 產品資料 | 500 g | |
| GC102004 | Sodium chloride | 產品資料 | 500 g | |
| GC101004 | Magnesium Sulfate | 產品資料 | 100 g | |
| GC101013 | Ammonium persulfate | 產品資料 | 25 g | |
| GC105001 | Sodium phosphate monobasic | 產品資料 | 500 g | |
| GC105002 | Sodium Phosphate, Dibasic | 產品資料 | 500 g | |
| GC105003 | Potassium Phosphate Monobasic | 產品資料 | 500 g | |
| GC107001 | Sodium hydroxide | 產品資料 | 100 g | |
| GC306001 | Lodixanol | 產品資料 | 5 g | |
| GC310001-100g | skimmed milk powder | 產品資料 | 100 g |