磷酸甘油酸變位酶 1 (PGAM1) 抗體 | Abbexa貨號abx002946
Phosphoglycerate Mutase 1 (PGAM1) Antibody

糖酵解(Glycolysis )是癌細胞的優選代謝模式。磷酸甘油酸變位酶 1 (Phosphoglycerate mutase 1, PGAM1) 是一種關鍵的糖酵解酶，可催化 2-磷酸甘油酸(2-phosphoglycerate)和 3-磷酸甘油酸(3-phosphoglycerate.)之間的相互轉化。它還刺激合成代謝(anabolic pathways)途徑，產生三磷酸腺苷(adenosine triphosphate)，並在缺氧條件下保持氧化還原平衡。越來越多的證據表明 PGAM1 在許多癌症中過度表達並促進其進展。PGAM1 在腫瘤發生中的關鍵作用使其成為有前景的癌症治療診斷靶點。PGAM1的異常表達使其成為多種癌症的潛在診斷基因，其通過與其不同配體相互作用的異質性調控增加了其作為癌症治療靶點和發現數十種PGAM1抑制劑的可能性。這可以為癌症治療提供潛在的可行性。(summary by Guan-Jun Yang et al., 2022 [PubMed 36215859])

PGAM1 Antibody 是針對 PGAM1 的兔多克隆抗體。

Target	PGAM1
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000 – 1/2000, IF/ICC: 1/50 – 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant protein of human PGAM1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P18669 (UniProt, ExPASy)
UniProt Secondary AC	Q9BWC0
UniProt Entry Name	PGAM1_HUMAN
Gene Symbol	PGAM1
GeneID	5223
KEGG	hsa:5223
String	9606.ENSP00000359991
Molecular Weight	Calculated MW: 28 kDa Observed MW: 31 kDa
Buffer	PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration	> 0.5 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.