抑肽酶(Aprotinin)| CAS#9087-70-1 Abcam 貨號ab146286

Aprotinin, serine protease inhibitor (ab146286)

抑肽酶(Aprotinin)抑制多種蛋白水解酶( proteolytic enzymes)的活性，例如胰凝乳蛋白酶(chymotrypsin)、激肽釋放酶(kallikrein)、纖溶酶(plasmin)和胰蛋白酶(trypsin)。它存在於血液( blood)和大多數組織( tissues)中，在肺，抑制促炎細胞因子釋放( pro-inflammatory cytokine )並維持糖蛋白穩態。在血小板(platelets)、抑肽酶( aprotinin)減少糖蛋白損失（例如 GpIb、GpIIb/IIIa），而在粒細胞中它阻止促炎粘附糖蛋白的表達。抑肽酶( aprotinin)是一種天然的由 58 個氨基酸排列成一個單一的蛋白酶抑制劑多肽多肽鏈，由三個二硫鍵交聯，分子量為6512 道爾頓。抑肽酶( aprotinin)通過專有色譜技術純化。它一直發現在體外抑制 SARS-CoV 和 SARS-CoV-2。

abID	ab49828
Alternate Name	Pancreatic trypsin inhibitor, Basic protease inhibitor, BPI, BPTI, Aprotinin, AP
Source	Bovine lung
Appearance	Lyophilized protein
Physical Form Description	Sterile filtered and lyophilized with no additives
Molecular Weight	6.5 kDa
Purity by SDS-PAGE	≥98%
Purity by	≥98%
Endotoxin Level	<0.1 ng/μg
Biological Activity	5 x 10⁶ IU/mg.
Reconstitution Instructions	Reconstitute in H₂O to a concentration of 1 mg/ml. The solution can then be diluted into other aqueous buffers and store at 4°C for 1 week or –20°C for future use. For long-term storage, it is recommend to add a carrier protein (e.g., 0.1% BSA). Prevent freeze/thaw cycles.
Handling	Centrifuge the vial prior to opening.
Storage Conditions	-20°C
Shipping Conditions	Gel Pack