Anti-Myc Tag Antibody (Mouse Monoclonal)單株抗體 | 貨號G019 100UG

該基因編碼的蛋白質是一種多功能的核磷蛋白(nuclear phosphoprotein)，在細胞週期進程(cell cycle progression)，細胞凋亡(apoptosis)和細胞轉化(cellular transformation) 中起作用。調節特定靶基因轉錄的轉錄因子(transcription factor)的作用。該基因的突變(Mutations)，過度表達(overexpression)，重排(rearrangement)和易位(translocation)與多種造血腫瘤(hematopoietic tumors)，白血病(leukemias)和淋巴瘤(lymphomas)（包括Burkitt lymphoma.伯基特淋巴瘤）有關。有證據表明，來自上游，框內非AUG（CUG）和下游AUG起始位點的替代翻譯起始導致產生具有不同N末端的兩個同工型。非AUG起始蛋白的合成在伯基特氏淋巴瘤中受到抑制，表明其在該基因正常功能中的重要性。由RefSeq提供，2008年7月。

Product Name	Anti-Myc Tag Antibody (Mouse Monoclonal)
Description	The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt’s lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]
Subtype	tag
Application	WB, ICC/IF, IP, ELISA,
Recommended Dilution	Western Blot (1:1000), Immunoprecipitation and Immunostaining (1:200). Other dilutions will need optimization by end user.
Raised In	mouse
Specificity	Myc-tag Monoclonal Antibody. Recognises over-expressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins in transfected mammalian cells.
Immunogen	A synthetic peptide corresponding to residues 410-419 (EQKLISEEDL) coupled to KLH.
Formulation	Liquid
Quantity	100 μg
Clone	Myc.A7
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Concentration	100µg/100ul
Isotype	IgG1
Species Reactivity	other