【Z-VAD-FMK 】CAS# 187389-52-2 APExBIO/apexbt.com 貨號 A1902
雷帕黴菌（Rapamycin）| Romidepsin (FK228, depsipeptide) | Daptomycin | G-418 (80 S 核醣體延伸抑制劑)
Z-VAD-FMK | CAS# 187389-52-2 APExBIO/apexbt.com 貨號 A1902
Proteases系列產品
蛋白酶(Proteases)也稱為肽酶(peptidases)或蛋白水解酶(proteolytic enzymes)，由大量催化肽鍵水解(hydrolysis)並隨後導致蛋白質底物(protein substrates)降解為氨基酸(amino acids)的酶組成。蛋白酶(Proteases)與多種人類疾病有關，包括癌症(cancer)、神經退行性疾病(neurodegenerative disorders)、炎症性疾病(inflammatory diseases)和心血管疾病(cardiovascular diseases)。因此，許多蛋白酶抑制劑【小分子(small molecules)和蛋白質】已被鑑定為阻斷蛋白酶的活性(proteases)。蛋白酶抑制劑可以根據它們通過兩種一般機制抑制的蛋白酶類別分為不同的類型，即不可逆的“捕獲(trapping)”反應和可逆(reversible)的緊密結合反應。蛋白酶抑制劑已被用作治療蛋白酶相關疾病的診斷劑(diagnostic)或治療劑(therapeutic agents)。
Z-VAD-FMK | CAS# 187389-52-2 APExBIO 貨號 A1902
Product Citation+6
Z-VAD-FMK 是一種 ICE 樣蛋白酶抑制劑(ICE-like proteases)，可抑制由多種刺激物誘導的 THP.1 細胞凋亡(apoptosis)和 Fas 抗原誘導的 Jurkat T 細胞凋亡(apoptosis)。它通過阻止 proCPP32 活化為其活性形式來抑制細胞凋亡(apoptosis)，而不是通過直接阻止 CPP32 的蛋白水解作用來抑制細胞凋亡(apoptosis)。Z-VAD-FMK almost completely inhibited the formation of large kilobasepair induced by all four stimuli. Similarly Z-VAD-FMK almost completely inhibited the enhanced formation of large kilobasepair fragments induced by thapsigargin or cycloheximide in the presence of TLCK, in good agreement with its ability to inhibit apoptosis induced by these treatments. These stimuli also induced internucleosomal cleavage of DNA, which was inhibited by Z-VAD-FMK. These results suggested that an ICE-like protease(s) acts at a stage prior to the formation of large kilobasepair fragments of DNA3.
- 1. Jingchun Du, Yougui Xiang, et al. “RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis.” Nat Commun. 2021 Dec 3;12(1):7067. PMID:34862394
- 2. Xinxin Ren, Xiang Wang, et al. “Significance of TEAD Family in Diagnosis, Prognosis and Immune Response for Ovarian Serous Carcinoma.” Int J Gen Med. 2021 Oct 27;14:7133-7143. PMID:34737608
- 3. Du Yu, Yundi Zhao, et al. “C19orf66 Inhibits Japanese Encephalitis Virus Replication by Targeting -1 PRF and the NS3 Protein.” Virol Sin. 2021 Dec;36(6):1443-1455. PMID:34309824
- 4. Chunhua Shu, Rui Wang, et al. “The “Dextran-Magnetic Layered Double Hydroxide-Fluorouracil” Drug Delivery System Exerts Its Anti-tumor Effect by Inducing Lysosomal Membrane Permeability in the Process of Cell Death.” Biol Pharm Bull. 2021 Oct 1;44(10):1473-1483. PMID:34305072
- 5. Qionghui Zhan, Jaepyo Jeon, et al. “CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux.” Autophagy. 2022 Apr;18(4):726-744. PMID:34282994
- 6. Jia-yuan Zhang, Bo Zhou, et al. “The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.” Cell Res. 2021 Sep;31(9):980-997. PMID:34012073
| Storage | Store at -20°C |
| M.Wt | 467.49 |
| Cas No. | 187389-52-2 |
| Formula | C22H30FN3O7 |
| Synonyms | Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone,Z-Val-Ala-Asp(OMe)-FMK |
| Solubility | ≥23.37 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoate |
| SDF | Download SDF |
| Canonical SMILES | CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1 |
| Shipping Condition | Ship with blue ice, or upon other requests. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon. |
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| 品項 | CAS# | #貨號 | 應用 |
| Z-VAD-FMK | CAS# 187389-52-2 | 貨號 A1902 |
Proteases ICE-like proteases |
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| VX-765 | CAS# 273404-37-8 | 貨號A8238 | Caspase-1 inhibitor |