MK-1439/ Doravirine | CAS# 1338225-97-0 貨號B1250-25

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MK-1439/ Doravirine | CAS# 1338225-97-0 貨號B1250-25
產品介紹: MK-1439(也稱為Doravirine)是一種不可逆的逆轉錄酶抑制劑(non-reversible reverse transcriptase inhibitor),用於治療HIV / AIDS,針對野生型(WT),K103N和Y181C逆轉錄酶的IC50值為12、9.7和9.7 nM。 (RT)突變體。 在95%有效濃度為20 nM的條件下,它具有出色的抑制WT病毒複製的活性。 它還對10種不同的HIV-1亞型病毒(包括K103N,Y81C)具有抗病毒活性。
Alternate Name | 3-Chloro-5-((1-((4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl)oxy)benzonitrile; Doravirine |
Appearance | Pale yellow solid |
CAS # | 1338225-97-0 |
Molecular Formula | C₁₇H₁₁ClF₃N₅O₃ |
Molecular Weight | 425.75 |
Purity | ≥98% by HPLC |
Solubility | DMSO |
SMILES | CN1C(=NNC1=O)CN2C=CC(=C(C2=O)OC3=CC(=CC(=C3)C#N)Cl)C(F)(F)F |
InChi | InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28) |
InChi Key | ZIAOVIPSKUPPQW-UHFFFAOYSA-N |
PubChem CID | 58460047 |
Handling | Protect from air and light |
Storage Conditions | -20°C |
Shipping Conditions | Gel Pack |
USAGE | For Research Use Only! Not For Use in Humans. |