Fc Silent™ Antibodies: Turning down the background noise 只要訊號不要雜訊 (Engineered Fc Domain)

Anti-WNV Envelope protein DIII [E16]

Absoluted Antibody 提供一系列抗體商品，其中Fc Silent™ Antibodies系列；能有效降低非特異性Fc結合。Fc Silent™技術，為應用生物工程技術，將Fc receptors (FcγR, FcR)點突變，進而中止抗體與ADCC的功能；有效降低Fc所造成的背景訊號。Fc Silent™抗體應用於免疫細胞時flow cytometry、immunohistochemistry (IHC)資料顯示，有效降低非特異性之Fc結合，所造成的背景值。(訂購抗體前，請確認選擇抗體是否有Fc Silent™修飾標誌)

產品介紹 WNV Envelope protein DIII單株抗體 | 貨號Ab00674-3.0

Description: Recombinant monoclonal antibody to WNV Envelope protein DIII. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma E16.
Species and Isotype: Mouse IgG2b, kappa
Clone Number: E16
UniProt Accession Number of Target Protein: 
Published Application(s): NTRL; crystallography
Published Species Reactivity: West Nile virus
Immunogen: 
Specificity: This antibody binds to the Envelope protein DIII domain of West Nile virus.
Application Notes: This antibody binds to the DIII domain of the Envelope protein of West Nile Virus and neutralizes infection.
Antibody First Published in: 
Dowd et al. A Dynamic Landscape for Antibody Binding Modulates Antibody-Mediated Neutralization of West Nile Virus PLoS Pathog. 2011 Jun; 7(6): e1002111. PMID:21738473 Note on publication: Describes the characterization of the neutralizing effect of this antibody.

Purification: Protein A affinity purified
Supplied in: PBS with preservative (0.02% Proclin 300)
Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C
Concentration: See vial label.