TP-0903抑制劑 | CAS#1341200-45-0Biovision貨號9590-25
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特點
產品介紹: TP-0903是一種有效的選擇性AXLkinase Inhibitor抑制劑（IC 50 = 27nM）。 TP-0903誘導CLL B細胞的大量凋亡，LD50值為nanomolar範圍。 用TP-0903治療癌細胞在多個模型中逆轉間充質表型，並使癌細胞對用其它靶向藥物的治療敏感。TP-0903 is a potent and selective AXL Inhibitor (IC₅₀ = 27 nM). TP-0903 induces massive apoptosis in CLL B cells with LD₅₀ values of nanomolar ranges. Treatment of cancer cells with TP-0903 reverses the mesenchymal phenotype in multiple models and sensitizes cancer cells to treatment with other targeted agents.
| 分子量 | 516.06 | 儲存條件 | 參考CoA中推薦的條件進行儲存。 |
| 分子式 | C₂₄H₃₀ClN₇O₂S | ||
| CAS號 | 1341200-45-0 | ||
| 溶劑/溶解度 | DMSO (>5 mg/ml) |
| Alternate Name | 2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide |
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| Appearance | White solid |
| CAS # | 1341200-45-0 |
| Molecular Formula | C₂₄H₃₀ClN₇O₂S |
| Molecular Weight | 516.06 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>5 mg/ml) |
| SMILES | CN1CCN(CC1)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)N(C)C)Cl |
| InChi | InChI=1S/C24H30ClN7O2S/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32/h4-11,16H,12-15,17H2,1-3H3,(H2,26,27,28,29) |
| InChi Key | YUAALFPUEOYPNX-UHFFFAOYSA-N |
| PubChem CID | 56839178 |