甲磺酸去鐵胺(Deferoxamine mesylate) | CAS#138-14-7 APExBIO貨號B6068
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甲磺酸去鐵胺(Deferoxamine mesylate)| CAS#138-14-7 APExBIO貨號B6068
產品介紹
甲磺酸去鐵胺(Deferoxamine mesylate ) 是一種特異性的鐵螯合劑 ( iron-chelating agent) [1][2][3] 甲磺酸去鐵胺(Deferoxamine mesylate )可用於治療急性鐵中毒。去鐵胺與鐵絡合形成鐵胺，阻止鐵參與進一步的化學反應。形成的螯合物易溶於水，並能輕鬆通過腎臟[1]。在移植了13762NF乳癌細胞的Fisher大鼠中，甲磺酸去鐵胺(Deferoxamine mesylate ) 抑制了該大鼠的腫瘤生長。而注射甲磺酸去鐵胺(Deferoxamine mesylate ) 合併低鐵飲食對腫瘤生長的抑制效果最佳。甲磺酸去鐵胺(Deferoxamine mesylate ) 能是一種有效的乳癌化療藥物[2]。在Sprague-Dawley大鼠中，手術前經腹腔動脈注射甲磺酸去鐵胺(Deferoxamine mesylate ) （75-90毫克；300毫克/公斤）。甲磺酸去鐵胺(Deferoxamine mesylate ) 顯著降低原位肝臟自體移植術後血清澱粉酶、脂肪酶和丙二醛 (MDA) 水平。甲磺酸去鐵胺(Deferoxamine mesylate ) 也透過上調 HIF-1 蛋白表現和抑制氧化毒性反應來保護胰臟組織 [3]。
- 1. Chao Wang, Yin-Lin Zha, et al. “Carfilzomib promotes Iodine-125 seed radiation-induced apoptosis, paraptosis, and ferroptosis in esophageal squamous cell carcinoma by aggravating endoplasmic reticulum stress.” Transl Oncol. 2025 Jul:57:102393. PMID: 40315760
- 2. Wei Huang, Gaowen Qu, et al. “Kallistatin enhances the phagocytic function of macrophages by decreasing the expression of CD24 in gastric cancer cells via the HIF-1α signaling pathway.” bioRxiv. 05 Apr, 2024.
- 3. Hao Zheng, Jinming Liu, et al. “Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance.” Nat Cancer. 2024 Jan 30. PMID: 38291304
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- 6. Mingchao Mu, Qin Zhang, et al. “3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis.” Cancer Gene Ther. 2023 Aug 9. PMID: 37558749
- 7. Yu Zhang, Xiyou Du, et al. “A Vanadium-Based Nanoplatform Synergizing Ferroptotic-like Therapy with Glucose Metabolism Intervention for Enhanced Cancer Cell Death and Antitumor Immunity.” ACS Nano. 2023 Jun 5. PMID: 37272777
- 8. Fan Yu, Qianping Zhang, et al. “Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis.” Cell Discov. 2022 May 3;8(1):40. PMID: 35504898
- 9. Binghua Liu, Weiyan Wang, et al. “Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells.” Cell Death Dis. 2021 Mar 3;12(3):230. PMID: 33658488
- 10. Junhong Zhang, Ni Wang, et al. “Oridonin induces ferroptosis by inhibiting gamma‐glutamyl cycle in TE1 cells.” Phytother Res 2020 Aug 31. PMID: 32869425
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| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 656.79 |
| Cas No. | 138-14-7 |
| Formula | C26H52N6O11S |
| Solubility | ≥65.7 mg/mL in H2O; insoluble in EtOH; ≥29.8 mg/mL in DMSO |
| Chemical Name | (Z)-4-((5-aminopentyl)(hydroxy)amino)-N-(5-((Z)-N,4-dihydroxy-4-((5-(N-hydroxyacetamido)pentyl)imino)butanamido)pentyl)-4-oxobutanimidic acid compound with methanesulfonic acid (1:1) |
| SDF | Download SDF |
| Canonical SMILES | CC(N(O)CCCCC/N=C(O)/CCC(N(O)CCCCC/N=C(O)/CCC(N(O)CCCCCN)=O)=O)=O.CS(O)(=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
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