Mouse GM-CSF protein重組蛋白- HEK293 Cells|貨號PRP100489

Csfgm; Gm-CSf; GMCSF; MGI-IGM; Granulocyte-macrophage colony-stimulating factor; CSF2

粒細胞巨噬細胞集落刺激因子 (Granulocyte-macrophage colony-stimulating factor,  GM-CSF) 是一系列細胞因子中的一種，在胚胎植入(embryo implantation )和後續發育( subsequent development)中發揮著關鍵作用。生殖道(reproductive tract )和妊娠組織(gestational tissues)中的幾種細胞譜系在源自男性精液和孕體的卵巢類固醇激素和信號劑的指導下合成 GM-CSF。植入前的胚胎、侵入的胎盤滋養層細胞和控制母體免疫耐受的大量白細胞都受到 粒細胞巨噬細胞集落刺激因子 (Granulocyte-macrophage colony-stimulating factor,  GM-CSF) 的調節。 粒細胞巨噬細胞集落刺激因子 (Granulocyte-macrophage colony-stimulating factor,  GM-CSF) 刺激造血祖細胞分化為單核細胞和中性粒細胞，並降低癌症患者出現發熱性中性粒細胞減少症的風險。 GM-CSF 還被證明可以誘導髓樣樹突狀細胞 (myeloid dendritic cells, DC) 的分化，從而促進同源 T 細胞中 T 輔助細胞 1 型（細胞）免疫反應的發展。該蛋白的活性形式在細胞外以同型二聚體形式存在，編碼基因位於染色體 5q31 區域的相關基因簇，已知該區域與 5q 綜合徵和急性髓性白血病有關。作為免疫/炎症級聯的一部分，粒細胞巨噬細胞集落刺激因子 (Granulocyte-macrophage colony-stimulating factor,  GM-CSF) 促進 Th1 偏向免疫反應、血管生成、過敏性炎症和自身免疫的發展，因此值得考慮作為治療靶點。 GM-CSF 已用於多種疾病過程的臨床管理。最近，粒細胞巨噬細胞集落刺激因子 (Granulocyte-macrophage colony-stimulating factor,  GM-CSF) 已作為單一療法以及疫苗佐劑被納入惡性腫瘤的治療中。雖然 GM-CSF 在這一領域的好處一直很有希望，但最近的報告表明 GM-CSF 有可能誘導免疫抑制，從而對癌症患者的治療結果產生負面影響。妊娠期 GM-CSF 缺乏會對胎兒和胎盤發育以及後代活力和出生後生長產生不利影響，這凸顯了該細胞因子是妊娠結局的核心母體決定因素，與人類生育能力具有臨床相關性。

Abbkine 為您提供細胞因子(Cytokine)，包括白細胞介素、趨化因子、集落刺激因子 (CSF)、干擾素、轉化生長因子 (TGF) 和腫瘤壞死因子 (TNF)，用於癌症、細胞凋亡、內分泌學、免疫學、神經科學、蛋白酶和幹細胞研究。這些細胞因子經每微克蛋白質內毒素，LAL法測定含量小於1.0EU。純度在95%以上，每個細胞因子都配備了1 mL與細胞因子最相容的再溶解緩衝液，因此再溶解後產品性能更穩定。過嚴格驗證，可滿足開發人員對高質量、高生物活性和有競爭力的價格的需求。

(Animal-Free) Abbkine細胞培養物（真核細胞）的非動物細胞因子(Animal-free cytokines)是利用非動物(non-animal)原料和表達系統生產的，表達系統中的培養基是無血清、無動物、化學成分透明的。

表達源自小鼠CSF2 (NP_034099.2) (Met1-Lys141)的氨基酸序列。重組小鼠 CSF2 由 124 個氨基酸組成(HEK293 Cells)，預計分子量為 14.1 KDa。在還原條件下，它在 SDS-PAGE 中遷移為大約 20.7 KDa 。使用 FDC-P1 細胞進行細胞增殖測定。此效應的 ED50 通常為 0.012-0.047 ng/mL。此效應的 ED50 通常為 0.012-0.047 ng/mL。

Product name	Mouse GM-CSF protein
Immunogen	PRP100489
Sequence	Amino acid sequence derived from mouse CSF2 (NP_034099.2) (Met1-Lys141) was expressed.
Activity	Measured in a cell proliferation assay using FDC-P1 cells. The ED50 for this effect is typically 0.012-0.047 ng/mL. The ED50 for this effect is typically 0.012-0.047 ng/mL.
Protein length	The recombinant mouse CSF2 consists of 124 amino acids and predicts a molecular mass of 14.1 KDa. It migrates as an approximately 20.7 KDa band in SDS-PAGE under reducing conditions.
Preparation method	HEK293 Cells
Purity	> 95 % as determined by SDS-PAGE
Alternative	Csfgm; Gm-CSf; GMCSF; MGI-IGM; Granulocyte-macrophage colony-stimulating factor; CSF2

 

Formulation	Lyophilized from sterile PBS, pH 7.4.
Molecular weight	14.1 kDa
Usage notes	Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Mouse GM-CSF protein in sterile ddH2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage instructions	Lyophilized Mouse GM-CSF proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.90% HSA or BSA). Please prevent freeze-thaw cycles.
Shipping	The product is shipped at ambient temperature.

細胞因子(Cytokine)

細胞因子(Cytokine)作為一種獨特的細胞信號轉導(cell signal transduction)分子，在細胞增殖(cell proliferation)和發育(development)中發揮著重要作用。 Abbkine 為癌症、細胞凋亡、內分泌學、免疫學、神經科學、蛋白酶和乾細胞研究提供細胞因子，包括白細胞介素(interleukin)、趨化因子(chemokine)、集落刺激因子 (colony stimulating factor , CSF)、干擾素(interferon)和轉化生長因子 (transforming growth factor , TGF) 和腫瘤壞死因子 (tumor necrosis factor , TNF) 家族。Abbkine 為您提供細胞因子(Cytokine)，包括白細胞介素、趨化因子、集落刺激因子 (CSF)、干擾素、轉化生長因子 (TGF) 和腫瘤壞死因子 (TNF)，用於癌症、細胞凋亡、內分泌學、免疫學、神經科學、蛋白酶和幹細胞研究。這些細胞因子經每微克蛋白質內毒素，LAL法測定含量小於1.0EU。純度在95%以上，每個細胞因子都配備了1 mL與細胞因子最相容的再溶解緩衝液，因此再溶解後產品性能更穩定。過嚴格驗證，可滿足開發人員對高質量、高生物活性和有競爭力的價格的需求。(Animal-Free) Abbkine細胞培養物（真核細胞）的非動物細胞因子(Animal-free cytokines)是利用非動物(non-animal)原料和表達系統生產的，表達系統中的培養基是無血清、無動物、化學成分透明的。

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