(-)-表沒食子兒茶素沒食子酸酯 (EGCG) | CAS#989-51-5 APExBIO貨號A2600
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(-)-表沒食子兒茶素沒食子酸酯 (EGCG) –(-)-Epigallocatechin gallate (EGCG)
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(-)-Epigallocatechin gallate (EGCG)| CAS#989-51-5 APExBIO貨號A2600
(-)-表沒食子兒茶素沒食子酸酯((-)-Epigallocatechin gallate, EGCG)是綠茶中主要的兒茶素(green tea)，佔綠茶兒茶素總量的59%，是一種強大的抗氧化劑(powerful antioxidant )、抗血管生成劑(antiangiogenic)和抗腫瘤劑(antitumor agent)。人們已經研究了 EGCG 在化學預防多種癌症方面的作用，包括肝癌( liver cancers)、胃癌( stomach cancers)、皮膚癌(skin cancers)、肺癌( lung cancers)、乳腺癌(mammary gland cancers)和結腸癌(colon cancers)。研究結果表明，EGCG能夠通過影響信號轉導途徑誘導細胞凋亡(apoptosis)、促進細胞生長停(* cell growth arrest)並阻止癌變(carcinogenesis )。此外，EGCG 對多種病毒具有抑制作用，包括 HCV、HIV-1、HBV、HSV-1、HSV-2、EBV、腺病毒、流感病毒和腸道病毒，以及多種酶，包括 DNMT、蛋白酶和 DHFR。
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 458.37 |
| Cas No. | 989-51-5 |
| Formula | C22H18O11 |
| Synonyms | EGCG |
| Solubility | ≥22.9 mg/mL in DMSO; ≥10.9 mg/mL in H2O with ultrasonic; ≥6.76 mg/mL in EtOH with ultrasonic |
| Chemical Name | [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate |
| SDF | Download SDF |
| Canonical SMILES | OC1=CC(O)=C(C[C@@H](OC(C2=CC(O)=C(O)C(O)=C2)=O)[C@@H](C3=CC(O)=C(O)C(O)=C3)O4)C4=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon. |
(-)-Epigallocatechin gallate (EGCG)| CAS#989-51-5
| Cell experiment [1]: | |
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Cell lines |
Human and rat neural progenitor cells (NPCs) |
| Preparation method | The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
| Reaction Conditions | 0, 1, 2, 5 and 10 μM; 24 or 48 hrs |
| Applications | (-)-Epigallocatechin Gallate (EGCG) altered human and rat NPC development in vitro. EGCG affected migration distance, migration pattern and nuclear density of NPCs growing as neurospheres. EGCG exerted these functional impairments by binding to the extracellular matrix (ECM) glycoprotein laminin, preventing its binding to β1-integrin subunits, thereby prohibiting cell adhesion and resulting in altered glia alignment and decreased number of migrating young neurons. |
| Animal experiment [2]: | |
| Animal models | A rat model of partial bladder outlet obstruction (pBOO)-induced bladder injury |
| Dosage form | 4.5 mg/kg/day; i.p.; 2 days or 30 days |
| Applications | EGCG attenuated bladder inflammation caused by pBOO at the 48th hr. At the 30th day, EGCG attenuated endoplasmic reticulum (ER) stress-related apoptosis. In addition, EGCG improved bladder compliance, contractile frequency and inflammation at the 30th day. |
| Other notes | Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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