LDHA-人類重組蛋白 Recombinant Protein | 貨號6374-100

Catalyzes the final step of anaerobic glycolysis 

產品描述：在無氧糖酵解(anaerobic glycolysis)的最後步驟中，LDHA催化L-乳酸(L-lactate)和NAD轉化丙酮酸(pyruvate)和NADH。 LDHA主要位於肌肉組織(muscle tissue)中，是乳酸脫氫酶家族(lactate dehydrogenase family)的一部分。 LDHA的突變(Mutations)與勞力性肌紅蛋白尿(exertional myoglobinuria)有關。 LDH1在原發性血小板增多症(thrombocythemia)中減少。 LDHA通過雌激素(estrogen)作用的非基因組(non-genomic pathway)途徑誘導。 LDH-A活性的降低導致線粒體呼吸的刺激和線粒體膜電位的降低。

Cat # +Size	6374-100
Size	100 μg
Alternate Name	L-lactate dehydrogenase A chain, GSD11, LDH1, LDHM, PIG19.
Gene Symbol	LDHA
Gene ID	3939
Accession #	P00338
Source	E. Coli
Appearance	Liquid
Physical Form Description	0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol.
Molecular Weight	38.8 kDa (352 aa, 1-332 aa + His-Tag)
Purity by SDS-PAGE	≥95%
Biological Activity	Specific activity is >20 units/mg.
Amino Acid Sequence	MGSSHHHHHH SSGLVPRGSH MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LK
Handling	Centrifuge the vial prior to opening.
Storage Conditions	-20°C

引用文獻Li, Hongde et al. (2016) Drosophila larvae synthesize the putative oncometabolite L-2-hydroxyglutarate during normal developmental growth, Proc Natl Acad Sci U S A. 2017 Feb 7;114(6):1353-1358.

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