抗ALDH1A1抗體（ALDH1A1 / 1381）| 貨號A1424-100

Anti-ALDH1A1 Antibody (ALDH1A1/1381)

產品描述：醛脫氫酶（ALDH）是NAD（P）+依賴性酶，其通過將醛氧化成羧酸來使醛解毒。 ALDH1A1屬於ALDH酶，ALDH酶是一類進化上保守的酶， 19種ALDH存在於人體中，由19種同種型組成，以多種細胞器表達並具有不同的底物偏好。 ALDH1A1是一種細胞溶質酶，優先將視黃醛氧化成視黃酸。ALDH1A1位於細胞質(cytoplasm) ，線粒體 (mitochondria) 或細胞核(nucleus) 中。 ALDH1A1在許多器官的上皮細胞中表達，ALDH1A1主要在睾丸(testis)，腦(brain)，眼(eye)，肝(liver)，眼晶狀體，角膜，腎(kidney)的上皮細胞以及神經(neural)和造血幹細胞(hematopoietic stem cells)中表達。  ALDH1A1在腦多巴胺能神經元中高度表達，在那裡它產生分化和發育所需的視黃酸。 由ALDH1A1產生的視黃酸對於造血幹細胞的分化也是重要的。據報導，與腦膜瘤和滑膜肉瘤相比，ALDH1A1在孤立性纖維瘤（solitary fibrous tumor , SFT）和血管外皮細胞瘤（hemangiopericytoma , HPC）中的表達較高。 與CD34組合，ALDH1A1可用於SFT，HPC，腦膜瘤(meningioma)和滑膜肉瘤(synovial sarcoma)的分化。ALDH1A1是乙醛氧化的主要酶，乙醛是乙醇的有毒代謝產物。

 

Cat # +Size	A1424-100
Size	100 µg
Antibody Target	ALDH1A1
Alternate Name	Acetaldehyde dehydrogenase 1, AHD2, ALDC, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase family 1 member A1, ALDH-E1, ALDH1, ALDH1A1, epididymis luminal protein 12, epididymis luminal protein 9, epididymis secretory sperm binding protein Li 53e, HEL-S-53e, PUMB1, RALDH1, Retinal dehydrogenase 1
Host	Mouse
Antibody Type	Monoclonal
Isotype	Mouse IgG1
Immunogen	Purified recombinant fragment of human ALDH1A1 (aa 315-434)
Accession #	P00352
Gene ID	216
Appearance	Colorless liquid
Formulation	In 10 mM PBS with 0.05% BSA & 0.05% azide
Purification	Protein A/G purification
Species Reactivity	Human, Monkey, Rat
Application	FC, IF, IHC, WB
Positive Control	IHC: Human Colon and Testicular Carcinoma, WB: A549 cells
Application & Usage	FC: 0.5-1 ug/1X106 cells in 0.1 ml, IF: 1-2 ug/ml, WB: 0.5-1ug/m, IHC: (Formalin-fixed): 0.5-1 ug/ml for 30 minutes at RT
Handling	The antibody solution should be gently mixed before use.
Storage Conditions	-20°C