TNF-α轉化酶重組蛋白 | 貨號7607-100
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特點
TACE (TNF-α converting enzyme), human recombinant Involved in the processing of TNF-α at the surface of cells
產品描述：TACE（TNF-α轉換酶，ADAM17）是來自ADAM（解整合素和金屬蛋白酶）蛋白質家族的膜結合金屬蛋白酶。 它將26kDa II型膜結合的TNF-α前體裂解成分泌的17kDa成熟形式。 還已知TACE處理其他膜蛋白，包括TNF受體，TGF-α和澱粉樣蛋白前體。 重組活性未標記的TACE氨基酸序列來自Arg215至Asn651。 由於真核系統中的蛋白質翻譯後修飾，表觀分子量大於計算的MW。
| Alternate Name | Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme |
| Gene Symbol | ADAM17 |
| Gene ID | 6868 |
| Accession # | P78536 |
| Source | Insect cell |
| Appearance | Lyophilized powder |
| Physical Form Description | The untagged rh-TACE (TNF-alpha converting enzyme) is supplied as a lyophilized powder. |
| Molecular Weight | 62 kDa |
| Purity by SDS-PAGE | ≥90% |
| Biological Activity | Activity of TACE was tested using the synthetic peptide, Abz-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Dpa(Dnp)-NH2, as a substrate. |
| Reconstitution Instructions | With sterile deionized water at 0.1µg protein/µl. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -70°C |
| Shipping Conditions | Gel Pack |