PARP Antibody (Clone 839120)單株抗體 | 貨號6659-100

Monoclonal Antibody to detect PARP in human samples.

 產品描述：PARP是一種116 kDa核聚（ADP-核糖）聚合酶，似乎參與DNA修復以應對環境壓力。 該蛋白質可以在體外被許多ICE樣半胱天冬酶切割，並且是體內胱天蛋白酶-3的主要切割靶標之一。 在人PARP中，切割發生在Asp214和Gly215之間，其將PARP氨基末端DNA結合結構域（24kDa）與羧基末端催化結構域（89kDa）分開。 PARP幫助細胞維持生存能力; PARP的裂解促進細胞分解並且充當經歷細胞凋亡的細胞的標記。

Cat # +Size	6659-100
Size	100 μl
Antibody Target	PARP
Alternate Name	PARP1, ADPRT, PPOL, NAD (+) ADP-ribosyltransferase 1
Host	Mouse
Antibody Type	Monoclonal
Isotype	Mouse IgG1
Immunogen	E. coli-derived recombinant human PARP- Thr 373-Glu 540
Accession #	P09874
Gene ID	142
Appearance	Colorless liquid
Concentration	0.5 mg/ml
Formulation	100 µl of 0.5 mg/ml antibody in sterile PBS.
Purification	Protein A/G Purified Antibody
Species Reactivity	Human
Application	Western Blot, IHC
Positive Control	Western Blot: HeLa cell lysate, IHC: human breast tissue.
Application & Usage	WB: 1 µg/ml, IHC: 8-25 µg/ml.
Handling	The antibody solution should be gently mixed before use.
Storage Conditions	-20 °C
Shipping Conditions	Gel Pack