NFkB p65抗體（CLONE 2A12A7）| 貨號3012-100

產品描述：NFkB被鑑定為序列特異性轉錄激活因子，其結合B淋巴細胞中κ輕鏈基因的內含子增強子。 NFkB是異二聚體，其由50kDa DNA結合亞基（p50）和65kDa反式激活亞基（p65 / RelA）組成。 這兩個亞基都表現出與原癌基因c-Rel的序列同源性。 p50 / p65異二聚體作為與其抑製劑IkB的複合物以無活性形式保留在胞質溶膠中。 通過多種刺激物刺激細胞，例如脂多醣（LPS），促炎細胞因子和病毒感染。 IkB被蛋白體磷酸化並降解。 活性NFkB異二聚體易位到細胞核中並誘導基因表達。

Cat # +Size	3012-100
Size	100 µg
Antibody Target	NFkB p65
Alternate Name	RELA, NFKB3, MGC131774
Host	Mouse
Antibody Type	Monoclonal
Isotype	Mouse IgG1
Immunogen	Synthetic peptide from human NFkB
Accession #	NP_033071
Gene ID	19697
Appearance	Colorless liquid
Concentration	0.2 mg/ml
Formulation	100 µg (200 µg/ml) in PBS containing 1 mg/ml BSA and 1.5 mM sodium azide and 50% glycerol.
Purification	Affinity purified
Species Reactivity	Human, mouse, rat
Application	Western blot, Immunoprecipitation, Immunohistochemistry
Application & Usage	Western blot analysis (1-4 µg/ml). However, the optimal conditions should be determined individually. A431 cells can be used as a positive control.
Handling	The antibody solution should be gently mixed before use.