人類CellExp™IL-29，人類重組蛋白 | 貨號6473-50

Human CellExp™ IL-29, Human Recombinant A cytokine mediating adaptive immune response

產品描述：IL-29與I型乾擾素和IL-10家族密切相關。 IL-29的表達由病毒感染誘導，其與由白細胞介素10受體β（IL10RB）和白細胞介素28受體α組成的異二聚體II類細胞因子受體相互作用。 IL-29與I型IFN具有共同特徵，例如抗病毒活性，抗增殖活性和體內抗腫瘤活性。 IL-29的作用類似於IFN，但一般效果較差，並且在更有限的細胞系範圍內具有活性。 響應於病毒感染產生的IL-29激活單核細胞和巨噬細胞產生限制性細胞因子組，因此它是激活病毒感染部位先天性免疫反應的重要因素。 IFN-λ1抗病毒和抗增殖活性需要干擾素-λ2受體酪氨酸殘基。

Alternate Name	Interleukin-29, IL-29, IFN-Lambda 1, Interferon-Lambda 1, Cytokine ZCYTO21, IL29, IFNL1, ZCYTO21.
Gene Symbol	IFNL1
Gene ID	282618
Accession #	Q8IU54
Source	Human 293 cell expressed
Appearance	Lyophilized
Physical Form Description	Lyophilized in PBS.
Molecular Weight	29 and 35 kDa, monomer, glycosylated
Purity by SDS-PAGE	> 95%
Endotoxin Level	< 1.0 EU per 1 μg of protein
Biological Activity	ED₅₀ is typically 0.5 to 5 ng/mL. The specific activity was determined by the dose-dependent protection of the cytopathic effect on A549 cells (human lung adenocarcinoma epithelial cell line) that were challenged with encephalomyocarditis
Reconstitution Instructions	Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Handling	Centrifuge the vial prior to opening.
Storage Conditions	-20°C
Shipping Conditions	Gel Pack