【sRANKL/Annexin V/FGF1/FGF acidic protein重組蛋白】Abbkine台灣經銷
Abbkine建立了完整的蛋白表達平台，注重培養專業、優秀的技術人才。 先後開發了數百種優質重組蛋白產品，建立了一套完整的生產、質量控制和活性評價體系。 spot的種類越來越多。 目前，這些重組蛋白產品可用於人、小鼠、大鼠等物種的生物學研究，涵蓋免疫學、神經生物學、幹細胞研究、癌症研究等多個研究方向。
Annexin V
Annexin V是一種鈣離子依賴性磷脂結合蛋白(calcium ion-dependent phospholipid binding protein )，分子量為35~36KDa，可與PS磷脂酰絲氨酸(phosphatidylserine , PS)特異性結合，親和力高。 在正常細胞中，磷脂酰絲氨酸(phosphatidylserine , PS)僅分佈在細胞膜脂(lipid bilayer )雙層的內側。 在細胞凋亡(apoptosis)的早期階段，膜磷脂酰絲氨酸（membrane phosphatidylserine, PS）從脂質膜( lipid membrane)的內側轉向外側。 作為一種磷脂結合蛋白(phospholipid binding protein)，Annexin V 與磷脂酰絲氨酸(phosphatidylserine , PS)具有高親和力。 它通過暴露在細胞外的磷脂酰絲氨酸(phosphatidylserine , PS)與細胞凋亡早期的細胞膜結合。 因此，Annexin V 是檢測早期細胞凋亡的敏感指標。
Annexin V is a calcium ion-dependent phospholipid binding protein with a molecular weight of 35~36KDa, which can specifically bind to phosphatidylserine PS with high affinity. In normal cells, phosphatidylserine is only distributed on the inner side of the lipid bilayer of the cell membrane. In the early stage of cell apoptosis, the membrane phosphatidylserine (PS) turns from the inner side of the lipid membrane to the outer side. As a phospholipid binding protein, Annexin V has a high affinity with phosphatidylserine. It binds to the cell membrane of cells in the early stage of apoptosis through the phosphatidylserine exposed on the outside of the cell. Therefore, Annexin V is a sensitive indicator for detecting early cell apoptosis.
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Demonstration of the experiment results
Fig. Abbkine lyophilized annexin V protein, lyophilized at 37°C for 4 days, 37°C for 7 days, and A brand annexin V protein, are respectively labeled with AbFluor488 fluorescent dye for apoptosis staining using LinKine™ AbFluor™ 488 Labeling Kit (abbkine, KTL0520-10k) . Hela cells were treated with Biyuntian Cell Apoptosis Positive Control Kit (C0005, 1:1000 dilution) for 24 hours, then stained and observed by fluorescence microscope.
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| Product Name | Item No. |
| Terminal Deoxynucleotidyl Transferase (TdT) | PRP3002 |
| TUNEL Apoptosis Detection Kit (Orange Fluorescence) | KTA2011 |
| TUNEL Apoptosis Detection Kit (Green Fluorescence) | KTA2010 |
| Annexin V-AbFluor™ 488 Apoptosis Detection Kit | KTA0002 |
| Annexin V-AbFluor™ 555 Apoptosis Detection kit | KTA0003 |
Human FGF1/FGF acidic protein重組蛋白 |貨號PRP1001
Introduction to FGF21
FGF21 是成纖維細胞生長因子 (Fibroblast Growth Factor , FGFs) 家族的成員。 該家族的蛋白質具有廣泛的促有絲分裂(mitogenic )和細胞存活活性( cell survival activities)，並參與多種生物過程，如血管生成(angiogenesis)、傷口癒合(wound healing)、神經發育(neurodevelopment)和腫瘤( tumor occurrence )的發生。 大多數 FGF（FGF3-8、10、15、17-19、21-23）在 N 端具有典型的信號序列分泌蛋白(signal sequence secreted proteins)。 其中，成纖維細胞生長因子21（Fibroblast Growth Factor 21 , FGF 21）在肝臟特異性表達，通過脂肪組織和胰腺範圍降低血糖和甘油三酯(triacylglycerols)。 胰高血糖素(Glucagon )可改善胰島 B 細胞(pancreatic islet B cells)的功能，從而防止飲食引起的肥胖(diet-induced obesity )和胰島素抵抗(insulin resistance.)。 此外，FGF21 還被證明是一種主要的 5-羥色胺(serotonin)的內源性調節因子，在禁食和酮症(ketosis)中起關鍵作用。
FGF21 is a member of the Fibroblast Growth Factor (FGFs) family. The proteins of this family have a wide range of mitogenic and cell survival activities, and are involved in a variety of biological processes, such as angiogenesis, wound healing, neurodevelopment, and tumor occurrence and development. Most FGFs (FGF3-8, 10, 15, 17-19, 21-23) have typical signal sequence secreted proteins at the N-terminus. Among them, Fibroblast Growth Factor 21 (FGF 21) is specific in the liver Sexual expression, reducing blood sugar and triacylglycerols through the scope of adipose tissue and pancreas. Glucagon improves the function of pancreatic islet B cells, thereby preventing diet-induced obesity and insulin resistance. In addition, FGF21 has also been shown to be a major The endogenous regulatory factors of serotonin play a key role in fasting and ketosis.
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| Product Name | Item No. |
| Human FGF1/FGF acidic protein | PRP1001 |
| Human bFGF protein | PRP1010 |
| Mouse bFGF protein | PRP1011 |
| Rat bFGF protein | PRP1210 |
sRANKL重組蛋白 |Mouse RANKL protein 貨號PRP1114
Introduction to sRANKL
腫瘤壞死因子配體超家族成員 11(Tumor necrosis factor ligand superfamily member 11)，也稱為核因子受體激活劑 kappa-B 配體(nuclear factor receptor activator kappa-B ligand)、骨保護素配體(osteoprotegerin ligand)、TNFSF11、RANKL、TRANCE、OPGL 和 CD254，在多種細胞中表達，包括成骨細胞(osteogenic Cells)、成纖維細胞(fibroblasts)、活化的 T 細胞(activated T cells )和 骨髓基質細胞(bone marrow stromal cells )可以與誘餌受體 OPG (decoy receptor OPG)相互作用。 TNFSF11參與了許多基本的生物學過程，如調節T細胞與樹突狀細胞之間的相互作用、調節T細胞依賴性免疫反應以及增強惡性腫瘤體液高鈣血症中的骨吸收(bone resorption)。 TNFSF11還增強了樹突狀細胞刺激T細胞(Naive T cells)增殖的能力。
Tumor necrosis factor ligand superfamily member 11, also known as nuclear factor receptor activator kappa-B ligand, osteoprotegerin ligand, TNFSF11, RANKL, TRANCE, OPGL and CD254, expressed in a variety of cells, including osteogenic Cells, fibroblasts, activated T cells and bone marrow stromal cells can interact with the decoy receptor OPG. TNFSF11 participates in many basic biological processes, such as regulating the interaction between T cells and dendritic cells, regulating T cell-dependent immune responses and enhancing bone resorption in humoral hypercalcemia of malignant tumors. TNFSF11 also enhanced the ability of dendritic cells to stimulate the proliferation of naive T cells.
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Related product information
| Product Name | Item No. |
| Mouse RANKL protein | PRP1114 |
Abbkine建立了完整的蛋白表達平台，注重培養專業、優秀的技術人才。 先後開發了數百種優質重組蛋白產品，建立了一套完整的生產、質量控制和活性評價體系。 spot的種類越來越多。 目前，這些重組蛋白產品可用於人、小鼠、大鼠等物種的生物學研究，涵蓋免疫學、神經生物學、幹細胞研究、癌症研究等多個研究方向。
| Type | Related Products |
| Cytokines | Interleukin, tumor necrosis factor, growth factor, chemokine,Interferon, colony stimulating factor |
| Immune checkpoint | PD-1、PD-L1 |
| Target protein | CD38、CD20 |
| CD antigen | CD86、CD80、CD19、CD7/GP40、CD22 |
| Other recombinant proteins | LPT, TRAIL, LIF, etc. |