PON1對氧磷酶1螢光分析套組 | 貨號K999-100

Paraoxonase 1 (PON1) Activity Assay Kit (Fluorometric) Highly Sensitive; Includes Paraoxonase Positive Control

產品描述: 對氧磷酶1（PON1，EC 3.1.8.1）是在肝臟中合成並釋放到血流中的43kDa酶，其在血清中與高密度脂蛋白（HDL）顆粒結合。 PON1是具有廣譜水解酶活性的promiscuous enzyme混雜酶，其最初命名為其能夠水解高毒性有機磷化合物 (toxic organophosphorus compounds )；例如insecticide paraoxon和化學武器的各種神經毒劑。隨後已證明該酶催化脂質氫過氧化物 (lipid hydroperoxides) 和內酯(lactones)的水解。 PON1有助於保護血清HDL和LDL顆粒免受脂質過氧化，並通過水解高反應性促氧化劑同型半胱氨酸硫內酯抑制LDL相關蛋白的N-高半胱氨酸化。脂質過氧化物和同型半胱氨酰化蛋白質的積累觸發動脈炎症，並最終導致動脈粥樣硬化atherosclerosis，缺血性中風 ischemic stroke 和心肌梗塞myocardial infarction。 PON1活性被認為是肝功能和全身氧化應激的臨床生物標誌物。血清PON1活性的測量作為用於評價肝臟功能和心血管疾病風險的潛在試驗。BioVision的Paraoxonase 1活性測定試劑盒K999能夠快速測量PON1活性，利用螢光底物轉化為高螢光產物（Ex / Em = 368 / 460nm）。這確保比UV或比色測定顯著更大的靈敏度，並且消除對危險的有毒底物的需要。提供了選擇性PON1抑制劑用於驗證PON1比活性。該測定法易於進行，高通量適應性並且可以檢測最小250μU對PON1氧磷酶活性，樣品體積為5μl；可用於哺乳動物的血漿或血清檢品或純化後之重組Paraoxonase之定量。套組內包括Paraoxonase inhibitor, 2-hydroxyquinoline, and a stable， Paraoxonase做為實驗對照組。

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