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3X (DYKDDDDK) Peptide | CAS# 402750-12-3 APExBIO 貨號A6001

代理廠牌:
原廠連結:
http://biopioneer.com.tw/wp-content/uploads/downloads/2022/09/Apexbio-Catalog.xlsx
相關下載:

3X-DYKDDDDK操作手冊

特點

生化分析試劑系列商品->>3X (DYKDDDDK) Peptide

APExBIO Technology LLC 是一家領先的小分子抑制劑 (Small Molecule Inhibitors)/活化劑(Activators)、化合物庫( Compound Libraries)、胜肽(Peptides)、檢測試劑盒(Assay Kits)、螢光標記(Fluorescent Label)、酶(Enzymes)、修飾核苷酸(Modified Nucleotides)、mRNA 合成以及各種分子生物學工具的供應商。APExBIO提供廣泛的產品線,涵蓋 20 多個不同的研究領域,例如癌症(cancer)、免疫學(immunology)、神經科學(neurosciences)、細胞凋亡(apoptosis)和表觀遺傳學(epigenetics)等。公司總部位於美國德州休士頓USA (Houston, Texas),致力於服務全球客戶。高度重視產品品質。所有產品均遵循嚴格的生產指南,並附有分析證書、HPLC、質譜(Mass Spectrum)和HMNR以及體外驗證(in vitro validation)。 APExBIO產品已被《Nature》、《Cell》和《Science》等眾多頂級同行評審期刊引用。

3X (DYKDDDDK) Peptide | CAS# 402750-12-3 APExBIO  貨號A6001

DYKDDDDK-tag 系統使用一個短的、具親水8 氨基酸肽(8- amino-acid peptide),與目標蛋白質融合。 DYKDDDDK 肽與抗體 M1 結合。該系統的一個缺點是單克隆抗體純化基質不如其他純化基質穩定。一般來說,小標籤可以用特異性單克隆抗體檢測。為了改進對 DYKDDDDK 標籤的檢測,開發了 3x (DYKDDDDK) 系統。這個三串聯 DYKDDDDK 表位是親水的,22 個氨基酸長,可以檢測高達 10 fmol 的表達融合蛋白。 Pyrococcus furiosus 的 DYKDDDDK 標記的麥芽糖糊精結合蛋白結晶 ,晶體的質量與未標記蛋白質的晶體非常相似。最後,可以通過腸激酶處理去除 DYKDDDDK 標籤,腸激酶對肽序列的五個 C 末端氨基酸具有特異性。

  • 1. Wei Yuan, Qais Al-Hadid, et al. “TDRD3 promotes DHX9 chromatin recruitment and R-loop resolution.” Nucleic Acids Res. 2021 Sep 7;49(15):8573-8591. PMID:34329467
  • 2. Daniel L. Kober, Arun Radhakrishnan, et al. “Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing.” Cell. 2021 Jul 8;184(14):3689-3701.e22. PMID:34139175
  • 3. Haijing Guo, Jen-Hsuan Wei, et al. “Importin α phosphorylation promotes TPX2 activation by GM130 to control astral microtubules and spindle orientation.” J Cell Sci. 2021 Feb 19;134(4):jcs258356. PMID:33526712
  • 4. Wu Y, Jin S, et al. “Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression.” Autophagy. 2020;1-14. PMID:32476569
  • 5. Howard SM, Ceppi I, et al. “The internal region of CtIP negatively regulates DNA end resection.” Nucleic Acids Res. 2020;48(10):5485-5498. PMID:32347940
  • 6. Jesse R. Poganik, Alexandra K. Van Hall-Beauvais, et al. “The mRNA-binding protein HuR is a kinetically-privileged electrophile sensor.” Helvetica Chimica Acta.10.1002.

Storage Desiccate at -20°C
M.Wt 2861.87
Cas No. 402750-12-3
Formula C120H169N31O49S
Synonyms H-Met-Asp-Tyr-Lys-Asp-His-Asp-Gly-Asp-Tyr-Lys-Asp-His-Asp-Ile-Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys-OH
Solubility ≥25mg/ml in TBS (0.5M Tris-HCl, pH 7.4, with 1M NaCl), 1X TBS as recommended buffer.
Chemical Name 3X (DYKDDDDK) Peptide
SDF Download SDF
Shipping Condition Ship with blue ice, or upon other requests.
General tips For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. We do not recommend long-term storage for the solution, please use it up soon.

APExBIO台灣代理商:  https://www.apexbt.com/

APExBIO提供優質的胜肽和生物分析試劑,廣泛產品線如Protease、Chromatin/Epigenetics表觀遺傳學、MAPK Signal、DNA Damege/DNA repair、細胞凋亡、腫瘤生物學、Stem cell等研究領域, 還提供定制的服務,包括多肽合成,抗體的生產和檢測的發展。產品線DNA/RNA prep kit、Drug Screening panel、Bioactive peptides、Growth factors、Biotinylation Reagents、tag peptides、amino Acids、Growth factors等。APExBIO產品質量都伴隨著證書的分析,高效液相色譜,質譜,和HMNR數據。

A2601 Aclacinomycin A 57576-44-0 98.00% Topoisomerase I and II inhibitor
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A2612 MG-115 133407-86-0 98.00% Potent reversible proteasome inhibitor
A2614 Bortezomib (PS-341) 179324-69-7 99.89% Proteasome Inhibitor
A2623 VU 0364439 1246086-78-1 98.00% Positive allosteric mGluR-4 modulator
A2633 Brivanib Alaninate (BMS-582664) 649735-63-7 98.00% VEGFR2 inhibitor,ATP-competitive
A2664 VX-661 1152311-62-0 99.88% F508del CFTR corrector
A2673 AG-1024 65678-07-1 98.00% Selective IGF-1R inhibitor
A2678 SU11274 658084-23-2 ≥95.00% C-Met inhibitor,potent and selective
A2681 TGX-221 663619-89-4 98.91% PI3Kβ inhibitor,potent,selective and ATP competitive
A2689 Butein 487-52-5 98.00% Protein kinase inhibitor
A2700 10Panx 955091-53-9 99.29% Panx-1 mimetic inhibitor
A2701 Scrambled 10Panx 1315378-72-3 98.68% Panx-1 mimetic inhibitory peptide, blocks pannexin-1 gap junctions
A2754 TG100-115 677297-51-7 98.02% PI3Kγ/PI3Kδ inhibitor
A2782 Amonafide 69408-81-7 98.00% DNA intercalator,Topo II inhibitor
A2806 BX-912 702674-56-4 95.55% PDK1 inhibitor,potent and ATP-competitive
A2813 Ivermectin 70288-86-7 98.00% NAChR/purinergic P2X4 receptor modulator
A2822 AC480 (BMS-599626) 714971-09-2 98.00% HER1/2 inhibitor,selective and efficacious
A2838 OSI-930 728033-96-3 99.58% Inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck
A2842 Melatonin 73-31-4 99.81% Melatonin receptors agonist
A2845 Omeprazole 73590-58-6 97.37% H+,K+-ATPase inhibitor
A2846 OSU-03012 (AR-12) 742112-33-0 99.43% Potent PDK1 inhibitor
A2852 Leflunomide 75706-12-6 99.69% AHR agonist,immunosuppressive agent
A2884 Doxazosin Mesylate 77883-43-3 99.82% α1-adrenergic receptor antagonist
A2890 Nepafenac 78281-72-8 98.00% COX-1 and COX-2 inhibitor
A2917 Flumazenil 78755-81-4 99.85% Benzodiazepine antagonist
A2942 Masitinib (AB1010) 790299-79-5 99.60% Tyrosine kinase inhibitor, potent and selective
A2949 Linifanib (ABT-869) 796967-16-3 99.62% VEGFR/PDGFR inhibitor
A2960 Loratadine 79794-75-5 98.24% Peripheral HH1R antagonist
A2974 Foretinib (GSK1363089) 849217-64-7 98.36% VEGF and HGF receptor inhibitor
A2977 Cabozantinib (XL184, BMS-907351) 849217-68-1 98.60% VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor
A2986 ADL5859 HCl 850173-95-4 99.16% δ-opioid receptor agonist,selective
A3001 PCI-32765 (Ibrutinib) 936563-96-1 99.39% Bruton’s tyrosine kinase (BTK) inhibitor
A3002 ABT-888 (Veliparib) 912444-00-9 99.87% Potent PARP inhibitor
A3003 MDV3100 (Enzalutamide) 915087-33-1 99.78% Androgen receptor antagonist
A3004 Vemurafenib (PLX4032, RG7204) 918504-65-1 98.48% BRAF kinase inhibitor
A3005 CAL-101 (Idelalisib, GS-1101) 870281-82-6 99.91% PI3K inhibitor
A3006 GDC-0068 (RG7440) 1001264-89-6 99.06% Pan-AKT inhibitor,highly selective
A3007 ABT-263 (Navitoclax) 923564-51-6 98.02% Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w
A3008 Y-27632 dihydrochloride 146986-50-7;129830-38-2 99.08% ROCK1 inhibitor
A3009 Sorafenib 284461-73-0 99.87% Raf kinases and tyrosine kinases inhibitor
A3010 MK-2206 dihydrochloride 1032350-13-2 99.59% Akt1/2/3 inhibitor
A3011 CHIR-99021 (CT99021) 252917-06-9 98.32% GSK-3 inhibitor, Cell-permeable, ATP-competitive
A3012 Ruxolitinib (INCB018424) 941678-49-5 99.64% JAK inhibitor
A3013 PD0325901 391210-10-9 99.74% MEK inhibitor
A3014 BGJ398 872511-34-7 99.74% FGFR inhibitor ,potent and selective
A3015 BKM120 944396-07-0 98.01% Inhibitor of pan-Class I PI3K
A3016 PLX-4720 918505-84-7 98.70% BRAF kinase inhibitor
A3017 Dasatinib (BMS-354825) 302962-49-8 98.09% Src and BCR-Abl inhibitor
A3018 Trametinib (GSK1120212) 871700-17-3 98.98% MEK1 and MEK2 inhibitor, potent and selective
A3019 AT-406 (SM-406) 1071992-99-8 98.00% IAP inhibitor
A3021 GDC-0449 (Vismodegib) 879085-55-9 99.64% Hedgehog antagonist,potent and selective
A3022 Pazopanib (GW-786034) 444731-52-6 98.81% VEGFR/PDGFR/FGFR inhibitor
A3023 P005091 882257-11-6 99.67% Ubiquitin-specific protease 7 (USP7) inhibitor
A3100 (+)-MK 801 70449-94-4 99.38% Potent NMDA antagonist
A3104 (E)-2-Decenoic acid 334-49-6 98.00% Fatty acid identified in royal jelly
A3108 17 alpha-propionate 19608-29-8 98.00% Androgen antagonist
A3111 1alpha, 25-Dihydroxy VD2-D6 216244-04-1 98.00% Deuterated form of vitamin D
A3115 24, 25-Dihydroxy VD3 40013-87-4 98.00% Vitamin D analogue
A3118 3,3′-Diindolylmethane 1968-05-4 99.69% Anticancer and antineoplastic agent
A3119 360A 794458-56-3 98.00% G-quadruplex structures inhibitor
A3120 360A iodide 737763-37-0 98.56% G-quadruplex structures inhibitor
A3122 PI4KIII beta inhibitor 3 1245319-54-3 98.00% PI4KIII beta inhibitor
A3123 4′-Demethylepipodophyllotoxin 6559-91-7 99.32% Anti-cancer drug
A3124 5-hydroxypyrazine-2-carboxylic acid 34604-60-9 99.15% Metabolite of pyrazinamide (PZA)
A3125 5-Iodotubercidin 24386-93-4 98.34% Adenosine kinase inhibitor,potent
A3126 5-R-Rivaroxaban 865479-71-6 99.49% Factor Xa (FXa) inhibitor
A3130 A 438079 899507-36-9 98.00% P2X7 receptor antagonist,competitive and selective
A3131 A 438079 hydrochloride 899431-18-6 99.59% P2X7 receptor antagonist,competitive and selective
A3132 A 77-01 607737-87-1 99.50% Potent ALK5 inhibitor
A3133 A 83-01 909910-43-6 99.24% ALK-5 inhibitor
A3134 A-317491 475205-49-3 98.53% P2X3 and P2X2/3 receptor antagonist
A3135 A-443654 552325-16-3 99.79% Akt inhibitor,potent and selective
A3136 A-740003 861393-28-4 98.24% P2X7 receptor antagonist
A3138 A-867744 1000279-69-5 98.00% Allosteric Modulator
A3139 Abacavir 136470-78-5 99.89% Inhibitor of HIV reverse transcriptase
A3142 Acamprosate calcium 77337-73-6 99.78% GABA receptor agonist and modulator of glutamatergic systems
A3143 Adarotene 496868-77-0 99.24% Apoptosis inducer/DNA damage agent
A3145 Afatinib dimaleate 850140-73-7 99.49% EGFR inhibitor
A3146 AGI-6780 1432660-47-3 98.63% IDH2/R140Q mutation inhibitor
A3147 AH 6809 33458-93-4 98.00% EP and DP receptor antagonist
A3148 AIM-100 873305-35-2 98.95% Ack1 inhibitor
A3149 AKT inhibitor VIII 612847-09-3 99.73% Allosteric Akt kinase inhibitor
A3151 Alarelin Acetate 79561-22-1 99.88% Synthetic GnRH agonist
A3153 Aliskiren 173334-57-1 98.95% Direct renin inhibitor
A3155 ALK inhibitor 2 761438-38-4 98.00% ALK inhibitor, novel and selective
A3156 Alogliptin Benzoate 850649-62-6 98.00% DPP-4 inhibitor,selective and potent,antidiabetic drug
A3157 Alosetron 122852-42-0 98.00% 5-HT3 receptor antagonist
A3159 Alosetron Hydrochloride 122852-69-1 98.91% 5-HT3 receptor antagonist,potent and highly selective
A3162 Alvimopan 156053-89-3 99.67% Mu-opioid receptors antagonist
A3163 Alvimopan dihydrate 170098-38-1 98.00% μ-opioid receptor antagonist,peripherally acting
A3165 ALW-II-41-27 1186206-79-0 97.45% Eph receptor inhibitor
A3166 AM095 1345614-59-6 98.14% Potent LPA1 receptor antagonist
A3167 AM-095 free base 1228690-36-5 98.12% Potent LPA1 receptor antagonist
A3169 AM679 1206880-66-1 98.00% FLAP inhibitor
A3170 AM966 1228690-19-4 99.69% LPA1 antagonist, oral active, high affinity, selective,
A3171 Amadacycline 389139-89-3 99.46% Tetracycline antibiotic
A3173 AMD-070 558447-26-0 98.00% CXCR4 antagonist,potent and selective
A3174 AMD-070 hydrochloride 880549-30-4 98.00% CXCR4 antagonist,potent and selective
A3176 Ampalex 154235-83-3 98.54% Ampakine and nootropic
A3177 AN-2690 174671-46-6 98.60% Antifungal agent
A3178 AN-2728 906673-24-3 99.33% PDE4 inhibitor,anti-inflammatory compound
A3179 Anamorelin 249921-19-5 99.68% Ghrelin receptor agonist, synthetic, orally active
A3182 Anguizole 442666-98-0 98.00% Inhibitor of HCV replication
A3184 AR-A014418 487021-52-3 98.34% GSK3β inhibitor, ATP-competitive and selective
A3185 AR-C155858 496791-37-8 99.52% MCT1 and MCT2 inhibitor
A3188 ARRY-520 R enantiomer 885060-08-2 98.00% KSP inhibitor
A3189 AS 602801 848344-36-5 98.72% Jun Kinase Inhibitor
A3190 ASC-J9 52328-98-0 98.00% AR degradation enhancer,antiumor agent
A3191 Ascomycin(FK 520) 104987-12-4 98.00% Macrolide immunosuppressant,FK-520 analog
A3192 Asenapine hydrochloride 1412458-61-7 98.00% Atypical antipsychotic
A3193 ASP3026 1097917-15-1 99.38% ALK inhibitor,potent and selective
A3194 AST 487 630124-46-8 99.29% RET kinase inhibitor
A3195 Asunaprevir (BMS-650032) 630420-16-5 99.80% NS3 protease inhibitor
A3196 AT-101 90141-22-3 98.00% BH3-mimetic,gossypol enantiomer
A3197 AT7519 Hydrochloride 902135-91-5 99.80% Multi-CDK inhibitor
A3198 AT7519 trifluoroacetate 1431697-85-6 98.00% CDK/cyclin inhibitor
A3199 AT7867 dihydrochloride 1431697-86-7 98.00% Akt1 and p70S6K/PKA inhibitor
A3201 Atrasentan hydrochloride 195733-43-8 98.00% Endothelin receptor antagonist
A3202 Avermectin B1 71751-41-2 98.00% Insecticide
A3206 AVL-292 1202757-89-8 98.27% Btk inhibitor
A3208 Avosentan 290815-26-8 98.00% ETA receptor antagonist
A3209 AXL1717 477-47-4 98.07% IGF-1R inhibitor,orally active
A3210 AZ20 1233339-22-4 99.93% ATR inhibitor,potent and selective
A3214 AZD1152 722543-31-9 98.78% Aurora B kinase inhibitor,highly potent and selective
A3215 AZD7687 1166827-44-6 98.00% DGAT inhibitor,potent and selective
A3216 Balaglitazone 199113-98-9 99.62% PPAR-γ partial agonist
A3217 Balapiravir 690270-29-2 98.00% Polymerase inhibitor,anti-HCV
A3218 BAM7 331244-89-4 98.00% BAX activator,direct and selective
A3219 BAN ORL 24 475150-69-7 98.00% NOP receptor antagonist, potent and selective
A3220 Bardoxolone 218600-44-3 99.55% Once-a-day treatment for CKD
A3221 Bardoxolone methyl 218600-53-4 98.75% IKK inhibitor, potent antioxidant inflammation modulator
A3222 Baricitinib phosphate 1187595-84-1 99.59% JAK1/JAK2 inhibitor
A3227 BAY 61-3606 732983-37-8 98.45% Syk Inhibitor
A3228 BAY 61-3606 dihydrochloride 648903-57-5 98.00% Syk tyrosine kinase inhibitor
A3230 Bay 65-1942 HCl salt 600734-06-3 98.00% IKKβ kinase inhibitor
A3232 Bazedoxifene 198481-32-2 98.00% Estrogen receptor modulator
A3236 Benfotiamine 22457-89-2 99.76% Drug for painful nerve condition
A3237 Betulinic acid 472-15-1 98.00% Anti-HIV and antitumor compound,pentacyclic triterpenoid
A3238 BEZ235 Tosylate 1028385-32-1 98.28% MTOR/P13K inhibitor
A3239 B-HT 920 36085-73-1 98.00% D2 receptor agonist
A3240 BIBX 1382 196612-93-8 98.00% EGFR inhibitor,potent and selective
A3241 Bilobalide 33570-04-6 98.00% Neuroprotective agent
A3242 Bitopertin 845614-11-1 99.70% Glycine reuptake inhibitor(GlyT1)
A3244 Bivalirudin Trifluoroacetate 128270-60-0 98.07% Reversible thrombin inhibitor
A3246 BMN-673 8R,9S 1207456-00-5 99.75% Inactive form of BMN 673, used as negative control
A3248 BMS345541 hydrochloride 547757-23-3 99.57% IKK inhibitor,highly selective
A3250 BMS-509744 439575-02-7 98.00% Itk inhibitor,potent and selective
A3252 BMS-599626 Hydrochloride 873837-23-1 99.58% EGFR/HER2 inhibitor,potent and selective
A3253 BMS-626529 701213-36-7 98.01% HIV-1 attachment inhibitor
A3254 BMS-663068 864953-29-7 98.00% HIV-1 attachment inhibitor
A3256 BMS-690514 859853-30-8 98.00% HER/EGFR inhibitor
A3257 BMS-790052 dihydrochloride 1009119-65-6 99.81% HCV NS5A inhibitor
A3258 BMS-833923 1059734-66-5 99.84% Smoothened inhibitor
A3259 BMS-927711 1289023-67-1 98.99% CGRP receptor antagonist
A3260 BMX-IN-1 1431525-23-3 97.99% BMX (also termed ETK) kinase inhibitor
A3261 Boceprevir 394730-60-0 98.00% HCV protease inhibitor,potent and selective
A3263 BRAF inhibitor 918505-61-0 98.00% Potent B-raf inhibitor
A3264 B-Raf inhibitor 1315330-11-0 98.00% A B-Raf inhibitor
A3265 Brassinolide 72962-43-7 98.00% Plant growth regulator
A3266 BS-181 1092443-52-1 98.00% CDK7 inhibitor,highly selective
A3268 CAL-130 Hydrochloride 1431697-78-7 98.00% PI3K inhibitor
A3270 Calcifediol monohydrate 63283-36-3 99.43% Prehormone;vitamin D3 metabolite
A3271 Calcipotriol 112965-21-6 98.00% Vitamin D3 analog,regulates cell differentiation and proliferation
A3275 Calcium-Sensing Receptor Antagonists I 478963-79-0 98.00% CaSR antagonist
A3276 Canertinib dihydrochloride 289499-45-2 99.72% Pan-ErbB inhibitor, potent and selective
A3277 Capadenoson 544417-40-5 98.00% Adenosine A1 receptor agonist
A3278 Nonivamide (Capsaicin Analog) 2444-46-4 99.53% TRPV1 receptor agonist
A3279 Capsazepine 138977-28-3 99.25% TRPV1 ion channel antagonist
A3282 Cariprazine 839712-12-8 99.19% D2/D3 partial agonist,antipsychotic drug
A3284 Cathepsin S inhibitor 1373215-15-6 98.33% Blocks MHCII antigen presentation
A3285 CB 300919 289715-28-2 98.00% Potential therapy for ovarian cancer
A3286 CB30865 206275-15-2 98.00% Nampt inhibitor
A3287 CC-401 hydrochloride 1438391-30-0 98.00% JNK inhibitor
A3288 CC-930 899805-25-5 98.00% JNK inhibitor,potent and selective
A3289 CCG-63802 620112-78-9 98.00% RGS protein inhibitor
A3290 CCG-63808 620113-73-7 98.00% Reversible RGS inhibitor
A3291 CCT241533 1262849-73-9 98.00% Potent Chk2 inhibitor
A3292 CCT241533 hydrochloride 1431697-96-9 98.00% CHK2 kinase inhibitor, novel
A3293 CDK inhibitor II 1269815-17-9 98.00% CDK inhibitor
A3294 CDK9 inhibitor 1415559-43-1 98.00% CDK9 inhibitor
A3295 CDK9 inhibitor 2 1263369-28-3 98.00% CDK9 inhibitor
A3297 CEP-32496 hydrochloride 1227678-26-3 98.00% B-Raf/C-Raf inhibitor,highly potent
A3298 Cetirizine 83881-51-0 99.65% Antihistamine
A3300 Cevimeline hydrochloride hemihydrate 153504-70-2 98.00% Agonist of muscarinic receptor (M1/M3)
A3302 CGI-1746 910232-84-7 98.00% Btk inhibitor
A3303 CGP60474 164658-13-3 98.00% CDKs and PKC inhibitor, potent
A3304 CGS 21680 120225-54-9 98.00% Adenosine A2 receptor agonists,potent and selective
A3305 CHAPS 75621-03-3 97.71% Zwitterionic detergent for membrane proteins,nondenaturing
A3306 Chelerythrine Chloride 3895-92-9 99.36% PKC antagonist
A3307 CHIR-090 728865-23-4 99.37% Potent LpxC inhibitor
A3308 Choline Fenofibrate 856676-23-8 99.92% Choline salt of fenofibric acid
A3309 CHR-6494 1333377-65-3 98.00% Haspin inhibitor,potent ands selective
A3310 chroman 1 1273579-40-0 98.00% ROCK II inhibitor, highly potent and selective
A3311 CID-2858522 758679-97-9 98.00% NF-κB pathway inhibitor

 

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最新產品 NEW PRODUCTS

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  • p-Cresyl sulfate | CAS#3233-58-7 APExBIO貨號A8895
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