Bleomycin sulfate , BLENOXANE® | CAS# 9041-93-4 APExBIO貨號 A8331
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抗生素化合物系列商品->>Bleomycin sulfate
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Bleomycin sulfate , BLENOXANE® | CAS# 9041-93-4 APExBIO貨號 A8331
硫酸博來黴素 (Bleomycin sulfate , BLENOXANE®) 是由輪枝鏈黴菌菌株(streptomyces verticillus)產生的細胞毒性糖肽抗生素(cytotoxic glycopeptide antibiotics)的混合物(mixture)。已知該成分通過接近金屬(metals)和配位分子氧(coordinate dioxygen)來產生活性物質(active species)，從而導致 DNA 中的單鍊和/或雙鏈(double-stranded)斷裂。硫酸博來黴素(Bleomycin sulfate)處理通過抑制 DNA 和蛋白質合成(protein syntheses)導致大腸桿菌細胞伸長(elongation)和 HeLa 細胞增大 [enlargement 1]。
該成分與多柔比星(Hodgkin’s lymphoma)聯合治療霍奇金淋巴瘤(doxorubicin)、睾丸癌(testicular cancer)、鱗狀細胞癌(squamous cell carcinomas)、肺纖維化(pulmonary fiborosis)以及足底疣(plantar warts)的治療廣泛使用。例如，硫酸博來黴素也被證明具有對勞斯肉瘤病毒(Rous sarcoma virus)誘導的小鼠腹水肉瘤(mouse ascites sarcoma)有中度至顯著影響，特別是當 F1 雜交小鼠用作宿主動物時 [2]。此外，最近的研究支持促炎細胞因子(proinflammatory cytokines, IL-18 )和 IL-1beta 在硫酸博來黴素誘導的人和小鼠肺損傷(lung injury)機制中的作用 [3]。
參考：
References:
- Suzuki H, Nagai K, Yamaki H, Tanaka N, Umezawa H. Mechanism of action of bleomycin. Studies with the growing culture of bacterial and tumor cells. J Antibiot (Tokyo) 1968,21:379-386.
- Takeuchi M, Yamamoto T. Effects of bleomycin on transplantable mouse tumors. J Antibiot (Tokyo) 1968,21:631-637.
- Hoshino T, Okamoto M, Sakazaki Y, Kato S, Young HA, Aizawa H. Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice. Am J Respir Cell Mol Biol 2009,41:661-670.
- Purity = 98.94%
- COA (Certificate Of Analysis)
- HPLC
- MS (Mass Spectrometry)
- MSDS (Material Safety Data Sheet)
- Datasheet
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| Cat# | Product Name |
| A8743 | SYBR Safe DNA Gel Stain |
| A6001 | 3X (DYKDDDDK) Peptide |
| K1018 | Cell Counting Kit-8 (CCK-8) |
| A1902 | Z-VAD-FMK |
| A3008 | Y-27632 dihydrochloride |
| A6002 | DYKDDDDK tag Peptide |
| B8362 | 2’3′-cGAMP (sodium salt) |
| F4002 | Phos binding reagent (Phosbind) acrylamide |
| A8011 | Biotin-tyramide |
| A2585 | MG-132 |
| F4005 | Prestained Protein Marker (Triple color, EDTA free, 10-250 kDa) |
| B1274 | AP20187 |
| K1007 | Protease Inhibitor Cocktail(EDTA-Free,100X in DMSO) |
| B8226 | InstaBlue Protein Stain Solution |
| A3011 | CHIR-99021 (CT99021) |
| A3007 | ABT-263 (Navitoclax) |
| B1524 | Erastin |
| B6055 | TCEP hydrochloride |
| K1031 | Phusion high-fidelity DNA polymerase |
| B1387 | (-)-Blebbistatin |
| B4664 | T-5224 |
| A8183 | Trichostatin A (TSA) |
| B3699 | ISRIB (trans-isomer) |
| A1910 | Bromodomain Inhibitor, (+)-JQ1 |
| B1293 | Y-27632 |
| A8167 | Rapamycin (Sirolimus) |
| A7024 | HOAt |
| A7025 | HOBt (anhydrous) |
| A8331 | Bleomycin Sulfate |
| A4333 | CPI-613 |
| K1070 | 2X SYBR Green qPCR Master Mix |
| A8005 | Sulfo-NHS-SS-Biotin |
| B4653 | BV6 |
| B5965 | Tamoxifen |
| A1901 | Q-VD-OPh hydrate |
| A8950 | UM 171 |
| K1046 | RNase Inhibitor, Murine |
| A3317 | Clozapine N-oxide (CNO) |
| A2614 | Bortezomib (PS-341) |
| A8003 | Sulfo-NHS-LC-Biotin |
| A4154 | Olaparib (AZD2281, Ku-0059436) |
| A8012 | Biotin-XX Tyramide Reagent |
| K1101 | PreScission Protease (PSP) |
| A8627 | Bafilomycin A1 |
| A8001 | Sulfo-NHS-Biotin |
| A3017 | Dasatinib (BMS-354825) |
| A2576 | E-64 |
| K1051 | Cy3 TSA Fluorescence System Kit |
| K1034 | 2X Taq PCR Master Mix (with dye) |
| B7972 | Pseudo-UTP |
| A8173 | Romidepsin (FK228, depsipeptide) |
| A4219 | Birinapant (TL32711) |
| A4371 | Ferrostatin-1 (Fer-1) |
| A8200 | DAPT (GSI-IX) |
| A8249 | SB 431542 |
| K1008 | Protease Inhibitor Cocktail (EDTA-Free, 200X in DMSO) |
| A3133 | A 83-01 |
| A8192 | Staurosporine |
| B1054 | Resiquimod (R-848) |
| A3018 | Trametinib (GSK1120212) |
| A8184 | AICAR |
| K1025 | Direct Mouse Genotyping Kit |
| A2606 | Epoxomicin |
| A6006 | Hexa His tag peptide |
| A4393 | Paclitaxel (Taxol) |
| A8315 | NU7441 (KU-57788) |
| A4213 | Necrostatin-1 |
| A8885 | Ro 3306 |
| L1021 | DiscoveryProbe™ FDA-approved Drug Library |
| B1464 | KPT-330 |
| A8815 | SM-164 |
| B4879 | Blasticidin S HCl |
| A8793 | N3-kethoxal |
| K1047 | HyperScribe™ T7 High Yield RNA Synthesis Kit |
| A6004 | Influenza Hemagglutinin (HA) Peptide |
| B1036 | MLN4924 |
| A8178 | Panobinostat (LBH589) |
| A3963 | A-769662 |
| A3847 | SU5416 |
| B3252 | Dorsomorphin (Compound C) |
| B4758 | BAPTA-AM |
| A2513 | Geneticin, G-418 Sulfate |
| B6004 | PX-478 2HCl |
| A8955 | Z-YVAD-FMK |
| A8193 | ABT-737 |
| B2083 | Caspofungin Acetate |
| A8002 | NHS-Biotin |
| A8337 | CX-5461 |
| A8312 | Torin 1 |
| A2570 | Leupeptin, Microbial |
| K2170 | Alanine Aminotransferase (ALT or SGPT) Activity Colorimetric/Fluorometric Assay Kit |
| A4381 | FK866 (APO866) |
| B2143 | Tacrolimus (FK506) |
| A2571 | Pepstatin A |
| k1072 | First-Strand cDNA Synthesis Kit |
| A3003 | MDV3100 (Enzalutamide) |
| B5997 | Dyngo-4a |
| A3742 | Pyridostatin |