GCK（葡萄糖激酶）抗體 | 貨號3153-100
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GCK (Glucokinase) Antibody 產品描述：己糖激酶(Hexokinases)使葡萄糖(glucose)磷酸化(phosphorylate)以產生6-磷酸葡萄糖(glucose-6-phosphate)，從而使葡萄糖進入糖酵解途 (glycolytic pathway)。 GCK基因的可變剪接(splicing)產生三種組織特異性形式的葡萄糖激酶(glucokinase)，一種在胰島β細胞(pancreatic islet beta cells)中發現，兩種在肝臟(liver)中發現。 該蛋白質定位於線粒體(mitochondria)的外膜(outer membrane)。 與其他形式的己糖激酶(hexokinase)不同，該酶不受其產物6-磷酸葡萄糖(glucose-6-phosphate)的抑制，但在葡萄糖豐富時仍保持活性。 該基因的突變與非胰島素依賴型糖尿病（non-insulin dependent diabetes mellitus, NIDDM）有關，也稱為2型年輕成年型糖尿病（maturity onset diabetes of the young, type 2, MODY2）。 突變還與嬰兒持續性高胰島素低血糖症（hyperinsulinemic hypoglycemia of infancy, PHHI）相關。
| Cat # +Size | 3153-100 |
| Size | 100 µg |
| Antibody Target | GCK (Glucokinase) |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide selected from the N-terminal region of human GCK |
| Accession # | P35557 |
| Gene ID | 2645 |
| Appearance | Colorless liquid |
| Concentration | 0.25 mg/ml |
| Formulation | 100 µg (0.25 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse |
| Application | ELISA, Western blot, Immunohistochemistry, Flow cytometry, Immunofluorescence |
| Application & Usage | The antibody can be used for ELISA (0.25 µg/ml), Western Blotting (0.5 – 2.5 µg/ml), Immunohistochemistry (2.5 – 5.0 µg/ml), Immunoflurescence (1:10 – 1:50), and Flow cytometry. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
乾浴加熱水浴槽 | Finnpipette F3 微量分注器 | 試管振盪器 Vortex Mixer | Genereach迷你型微量離心機 | ELISA儀器
引用文獻
Huang et al., MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPAR . RNA, Mar 2015; 21: 385 – 400.